Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 12/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | TET3 | O43151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.42 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.42 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1770373 | 0.93 | HDAC4 (0.56) | HSD11B1HDAC4ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4445340 | 0.85 | HSD11B1 (0.53) | HSD11B1HDAC4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL1769917 | 0.83 | HSD11B1 (0.51) | HSD11B1HDAC4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL13545175 | 0.83 | HSD11B1 (0.51) | HSD11B1HDAC4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8506341 | 0.81 | HDAC4 (0.51) | HSD11B1HDAC4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL4436038 | 0.81 | APP (0.45) | HSD11B1ALDH1A1SMN1; SMN2LMNAOPRM1 | |
| SCHEMBL4438201 | 0.81 | HSD11B1 (0.46) | HSD11B1ALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL20564438 | 0.80 | HDAC4 (0.50) | HSD11B1HDAC4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL4555582 | 0.80 | AKR1C1 (0.53) | HSD11B1HDAC4SMN1; SMN2HTTLMNA | |
| SCHEMBL2321735 | 0.79 | HSD11B1 (0.59) | HSD11B1HDAC4ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255192-A1 | 2-(1-(4-chlorophenyl)cyclopropyl)-3-hydroxy-8-(trifluoromethoxy)quinoline-4-carboxylic acid; antiinflammtory agents; antagonists of the mammalian adhesion proteins | WYETH (US) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255192-A1 | 2-(1-(4-chlorophenyl)cyclopropyl)-3-hydroxy-8-(trifluoromethoxy)quinoline-4-carboxylic acid; antiinflammtory agents; antagonists of the mammalian adhesion proteins | VCAM1, ICAM1, SELE | HSD11B1 3386/4885HDAC4 2710/4885ALDH1A1 346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.