Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 17/20 | 0.45 |
| ▸ | THRB | P10828 | 14/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.45 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.36 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23217992 | 0.81 | TGFBR1 (0.43) | TGFBR1THRBMAPK14TGFBR2MAP3K20 | |
| SCHEMBL3945862 | 0.80 | TGFBR1 (0.65) | TGFBR1THRBMAPK14TGFBR2MAP3K20 | |
| SCHEMBL23217949 | 0.80 | TGFBR1 (0.66) | TGFBR1THRBMAPK14 | |
| SCHEMBL2526666 | 0.70 | THRB (0.43) | TGFBR1THRBMAPK14TGFBR2MAP3K20 | |
| SCHEMBL24348532 | 0.69 | TGFBR1 (0.56) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL14844882 | 0.67 | THRB (0.52) | TGFBR1THRBMAPK14 | |
| SCHEMBL22561233 | 0.66 | TGFBR1 (0.68) | TGFBR1THRBMAPK14TGFBR2MAP3K20 | |
| SCHEMBL29049906 | 0.64 | TGFBR1 (0.55) | TGFBR1THRBMAPK14 | |
| SCHEMBL17373680 | 0.64 | THRB (0.49) | TGFBR1THRBMAPK14 | |
| SCHEMBL19732288 | 0.64 | TGFBR1 (0.65) | TGFBR1THRBMAPK14TGFBR2MAP3K20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021072330-A1 | GALNAC-TGFBR1 INHIBITOR CONJUGATES FOR THE TREATMENT OF LIVER DISEASES | SILVERBACK THERAPEUTICS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |