Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 17/20 | 0.43 |
| ▸ | THRB | P10828 | 13/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.43 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.35 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | GAK | O14976 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | TGFB2 | P61812 | 1/20 | 0.33 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.33 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3949903 | 0.81 | TGFBR1 (0.62) | TGFBR1THRBMAPK14TGFBR2MAP3K20 | |
| SCHEMBL23217907 | 0.81 | TGFBR1 (0.45) | TGFBR1THRBMAPK14TGFBR2MAP3K20 | |
| SCHEMBL3941021 | 0.76 | THRB (0.57) | TGFBR1THRBMAPK14TGFBR2MAP3K20 | |
| SCHEMBL3942578 | 0.73 | THRB (0.53) | TGFBR1THRBMAPK14TGFBR2MAP3K20 | |
| SCHEMBL19732293 | 0.71 | THRB (0.58) | TGFBR1THRBMAPK14TGFBR2MAP3K20 | |
| SCHEMBL20893668 | 0.70 | TGFBR1 (0.44) | TGFBR1THRBMAPK14TGFBR2MAP3K20 | |
| SCHEMBL28938616 | 0.64 | TGFBR1 (0.70) | TGFBR1THRBMAPK14TGFBR2MAP3K20 | |
| SCHEMBL22561233 | 0.64 | TGFBR1 (0.68) | TGFBR1THRBMAPK14TGFBR2MAP3K20 | |
| SCHEMBL23217949 | 0.62 | TGFBR1 (0.66) | TGFBR1THRBMAPK14 | |
| SCHEMBL19732288 | 0.62 | TGFBR1 (0.65) | TGFBR1THRBMAPK14TGFBR2MAP3K20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076905-A1 | ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2022-04-14 | — | — | WO | disclosed |
| WO-2021072330-A1 | GALNAC-TGFBR1 INHIBITOR CONJUGATES FOR THE TREATMENT OF LIVER DISEASES | SILVERBACK THERAPEUTICS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |