Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.32 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
| ▸ | SKP1 | P63208 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | GLS | O94925 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 3/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23217897 | 0.85 | NPC1 (0.34) | TGFBR1PDPK1PCSK9CKS1BSKP1 | |
| SCHEMBL23217953 | 0.82 | PDK2 (0.36) | TGFBR1BCHECKS1BSKP1SKP2 | |
| SCHEMBL23217905 | 0.77 | CA12 (0.40) | BCHECKS1BSKP1SKP2KDM4E | |
| SCHEMBL8293584 | 0.75 | PCSK9 (0.42) | BCHESYKPCSK9P2RX7BRD4 | |
| SCHEMBL23217942 | 0.74 | TGFBR1 (0.47) | TGFBR1PDPK1 | |
| SCHEMBL14576794 | 0.71 | NPC1 (0.48) | TGFBR1P2RX7LMNA | |
| SCHEMBL17827871 | 0.70 | P2RX7 (0.48) | BCHEPCSK9CKS1BSKP1SKP2 | |
| SCHEMBL4920111 | 0.68 | PCSK9 (0.40) | GRM2BCHESYKPCSK9CKS1B | |
| SCHEMBL23389840 | 0.67 | NPC1 (0.40) | TGFBR1P2RX7LMNA | |
| SCHEMBL29796631 | 0.67 | NPC1 (0.40) | TGFBR1P2RX7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021072330-A1 | GALNAC-TGFBR1 INHIBITOR CONJUGATES FOR THE TREATMENT OF LIVER DISEASES | SILVERBACK THERAPEUTICS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |