Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 4/20 | 0.33 |
| ▸ | LATS1 | O95835 | 4/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ACACA | Q13085 | 1/20 | 0.32 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.32 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
| ▸ | SKP1 | P63208 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23217952 | 0.85 | TGFBR1 (0.33) | PDPK1NAMPTPCSK9CKS1BSKP1 | |
| SCHEMBL23217900 | 0.81 | GABRA5 (0.38) | NPC1NAMPTLATS1GABRA5CKS1B | |
| SCHEMBL23217910 | 0.76 | CA12 (0.40) | LATS1GABRA5CKS1BSKP1SKP2 | |
| SCHEMBL8293584 | 0.75 | PCSK9 (0.42) | ACACBACACAPCSK9GAAP2RX7 | |
| SCHEMBL23217942 | 0.75 | TGFBR1 (0.47) | PDPK1ACACBACACATGFBR1 | |
| SCHEMBL23217923 | 0.71 | NPC1 (0.40) | NPC1RAB9AKDM4EALDH1A1GAA | |
| SCHEMBL4858870 | 0.69 | NPC1 (0.60) | NPC1RAB9AKDM4EALDH1A1GAA | |
| SCHEMBL24214779 | 0.69 | STK17B (0.37) | NAMPTLATS1LATS2PCSK9CKS1B | |
| SCHEMBL4920111 | 0.68 | PCSK9 (0.40) | PCSK9CKS1BSKP1SKP2KDM4E | |
| SCHEMBL4916056 | 0.67 | HCAR3 (0.42) | NAMPTGABRA5GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022006340-A1 | ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2022-01-06 | — | — | WO | disclosed |
| WO-2021072330-A1 | GALNAC-TGFBR1 INHIBITOR CONJUGATES FOR THE TREATMENT OF LIVER DISEASES | SILVERBACK THERAPEUTICS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |