Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 7/20 | 0.59 |
| ▸ | FEN1 | P39748 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5198271 | 0.92 | TGFBR1 (0.70) | TGFBR1FEN1MAPK14 | |
| SCHEMBL29361356 | 0.92 | TGFBR1 (0.70) | TGFBR1FEN1MAPK14 | |
| SCHEMBL5199498 | 0.91 | TGFBR1 (0.56) | TGFBR1MAPK14 | |
| SCHEMBL5198295 | 0.90 | TGFBR1 (0.56) | TGFBR1FEN1 | |
| SCHEMBL23218007 | 0.88 | TGFBR1 (0.54) | TGFBR1FEN1MAPK14 | |
| SCHEMBL5198228 | 0.88 | TGFBR1 (0.52) | TGFBR1FEN1MAPK14ALOX5AP | |
| SCHEMBL24311916 | 0.87 | TGFBR1 (0.45) | TGFBR1FEN1KCNH2ALOX5AP | |
| SCHEMBL5200014 | 0.87 | TGFBR1 (0.53) | TGFBR1KDR | |
| SCHEMBL24311917 | 0.86 | TGFBR1 (0.56) | TGFBR1MAPK14TGFBR2 | |
| SCHEMBL24311929 | 0.86 | TGFBR1 (0.50) | TGFBR1MAPK14TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076905-A1 | ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2022-04-14 | — | — | WO | disclosed |
| WO-2021072330-A1 | GALNAC-TGFBR1 INHIBITOR CONJUGATES FOR THE TREATMENT OF LIVER DISEASES | SILVERBACK THERAPEUTICS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |