Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 0.56 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 11/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23218015 | 0.91 | TGFBR1 (0.59) | TGFBR1MAPK14 | |
| SCHEMBL29361356 | 0.90 | TGFBR1 (0.70) | TGFBR1PIM1MAPK14 | |
| SCHEMBL5198271 | 0.90 | TGFBR1 (0.70) | TGFBR1PIM1MAPK14 | |
| SCHEMBL5198295 | 0.88 | TGFBR1 (0.56) | TGFBR1 | |
| SCHEMBL24311917 | 0.88 | TGFBR1 (0.56) | TGFBR1PIM1MAPK14 | |
| SCHEMBL5198228 | 0.87 | TGFBR1 (0.52) | TGFBR1PIM1MAPK14THRB | |
| SCHEMBL24311918 | 0.87 | TGFBR1 (0.53) | TGFBR1PIM1MAPK14 | |
| SCHEMBL23218007 | 0.86 | TGFBR1 (0.54) | TGFBR1MAPK14 | |
| SCHEMBL5200014 | 0.85 | TGFBR1 (0.53) | TGFBR1PIM1PIM3PIM2MAPK1 | |
| SCHEMBL24312122 | 0.84 | TGFBR1 (0.51) | TGFBR1PIM1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275968-A1 | Substituted Biphenyl Derivative | SANKYO COMPANY, LIMITED (JP) | 2007-11-29 | — | — | US | disclosed |
| EP-1798229-A1 | SUBSTITUTED BIPHENYL DERIVATIVE | Sankyo Company, Limited (JP) | 2007-06-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275968-A1 | Substituted Biphenyl Derivative | COL2A1, COL1A1, FGFR3 | TGFBR1 40/4885ACSS2 1615/4885LRRK2 1354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.