Sugi Predict

Sugi Predict / Compounds / SCHEMBL23218101

SCHEMBL23218101

SCHEMBL23218101

CCOC(=O)Cc1ccccc1OCc1coc2c(OCc3nccs3)cc(Br)cc12

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TBXAS1 P24557 1/20 0.39
▸ CFD P00746 1/20 0.35
▸ MAPT P10636 6/20 0.35
▸ NPC1 O15118 1/20 0.35
▸ RAB9A P51151 1/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ MMP9 P14780 1/20 0.33
▸ MMP13 P45452 1/20 0.33
▸ ADAM17 P78536 1/20 0.33
▸ TSHR P16473 2/20 0.33
▸ PTGER1 P34995 2/20 0.33
▸ TP53 P04637 2/20 0.33
▸ THRB P10828 1/20 0.33
▸ MEN1 O00255 2/20 0.32
▸ KMT2A Q03164 2/20 0.32
▸ PIM1 P11309 1/20 0.32
▸ PIM2 Q9P1W9 1/20 0.32
▸ PKM P14618 1/20 0.31
▸ GAA P10253 1/20 0.31
▸ ALOX15 P16050 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29852692 1.00 TBXAS1 (0.39) TBXAS1CFDMAPTNPC1RAB9A
SCHEMBL29852821 0.86 PIM1 (0.44) TBXAS1CFDMAPTALDH1A1PTGER1
SCHEMBL29852558 0.86 TBXAS1 (0.40) TBXAS1CFDMAPTNPC1RAB9A
SCHEMBL23218485 0.86 TBXAS1 (0.40) TBXAS1CFDMAPTNPC1RAB9A
SCHEMBL23218270 0.86 PIM1 (0.44) TBXAS1CFDMAPTALDH1A1PTGER1
SCHEMBL23218656 0.86 PTGER1 (0.40) TBXAS1CFDMAPTNPC1RAB9A
SCHEMBL29852614 0.86 PTGER1 (0.40) TBXAS1CFDMAPTNPC1RAB9A
SCHEMBL29122209 0.85 TBXAS1 (0.36) TBXAS1CFDMAPTNPC1RAB9A
SCHEMBL23218928 0.84 TBXAS1 (0.41) TBXAS1CFDMAPTPTGER1TP53
SCHEMBL29853232 0.84 TBXAS1 (0.41) TBXAS1CFDMAPTPTGER1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12558341-B2 Oral complement factor D inhibitors BIOCRYST PHARMACEUTICALS, INC. (US) 2026-02-24 — — US disclosed
US-20250186391-A1 ORAL COMPLEMENT FACTOR D INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2025-06-12 — — US disclosed
US-20240239752-A1 BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 WILMINGTON TRUST, NATIONAL ASSOCIATION 2024-07-18 — — US disclosed
US-20240239752-A1 BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 WILMINGTON TRUST, NATIONAL ASSOCIATION 2024-07-18 — — US disclosed
CN-117120419-A KLK5 bicyclic heteroaromatic inhibitors 拜奥克里斯特制药公司 2023-11-24 — — CN disclosed
CN-114502168-A Oral complement factor D inhibitors 拜奥克里斯特制药公司 2022-05-13 — — CN disclosed
WO-2021072198-A1 ORAL COMPLEMENT FACTOR D INHIBITORS BIOCRYST PHARMACEUTICALS, INC. (US) 2021-04-15 — — WO disclosed
WO-2021072198-A1 ORAL COMPLEMENT FACTOR D INHIBITORS BIOCRYST PHARMACEUTICALS, INC. (US) 2021-04-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240239752-A1 BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 KLK5, KLK1, KLKB1 TBXAS1 2084/4885CFD 3529/4885MAPT 1734/4885
US-12558341-B2 Oral complement factor D inhibitors CFD, CFH, CFB TBXAS1 963/4885CFD 1/4885MAPT 4793/4885
US-20250186391-A1 ORAL COMPLEMENT FACTOR D INHIBITORS CFD, CFH, CFB TBXAS1 392/4885CFD 1/4885MAPT 3561/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.