Sugi Predict

Sugi Predict / Compounds / SCHEMBL23218138

SCHEMBL23218138

SCHEMBL23218138

CCOC(=O)Cc1ccc(OC)cc1OCc1coc2c(OCC3CC3)cc(Br)cc12

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ KDM4E B2RXH2 2/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ POLB P06746 2/20 0.35
▸ TDP1 Q9NUW8 1/20 0.35
▸ MAPT P10636 2/20 0.35
▸ PIM1 P11309 1/20 0.35
▸ PIM2 Q9P1W9 1/20 0.35
▸ ELANE P08246 1/20 0.34
▸ L3MBTL1 Q9Y468 2/20 0.34
▸ TSHR P16473 2/20 0.33
▸ CNR2 P34972 2/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ PDE3B Q13370 1/20 0.33
▸ PDE3A Q14432 1/20 0.33
▸ CNR1 P21554 1/20 0.33
▸ PDE4A P27815 1/20 0.33
▸ PDE4B Q07343 1/20 0.33
▸ PDE4C Q08493 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29853155 1.00 MEN1 (0.35) MEN1KMT2AKDM4EALDH1A1POLB
SCHEMBL23218538 0.91 PDE10A (0.36) MEN1KMT2AALDH1A1POLBMAPT
SCHEMBL29853118 0.91 PDE10A (0.36) MEN1KMT2AALDH1A1POLBMAPT
SCHEMBL29853281 0.90 MAPT (0.40) MEN1KMT2AKDM4EALDH1A1POLB
SCHEMBL23218855 0.90 MAPT (0.40) MEN1KMT2AKDM4EALDH1A1POLB
SCHEMBL23218843 0.88 PIM1 (0.36) MAPTPIM1PIM2CNR2THRB
SCHEMBL29853204 0.88 PIM1 (0.36) MAPTPIM1PIM2CNR2THRB
SCHEMBL23218310 0.86 MAPT (0.38) MEN1KMT2AKDM4EMAPTL3MBTL1
SCHEMBL29852986 0.86 MAPT (0.38) MEN1KMT2AKDM4EMAPTL3MBTL1
SCHEMBL23218714 0.84 CFD (0.39) MEN1KMT2AKDM4EL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12558341-B2 Oral complement factor D inhibitors BIOCRYST PHARMACEUTICALS, INC. (US) 2026-02-24 — — US disclosed
US-20250186391-A1 ORAL COMPLEMENT FACTOR D INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2025-06-12 — — US disclosed
CN-114502168-A Oral complement factor D inhibitors 拜奥克里斯特制药公司 2022-05-13 — — CN disclosed
WO-2021072198-A1 ORAL COMPLEMENT FACTOR D INHIBITORS BIOCRYST PHARMACEUTICALS, INC. (US) 2021-04-15 — — WO disclosed
US-20160361275-A1 SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY ACADIA PHARMACEUTICALS INC. 2016-12-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160361275-A1 SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY SLC6A4, HTR4, GPR34 MEN1 757/4885KMT2A 4413/4885KDM4E 1720/4885
US-12558341-B2 Oral complement factor D inhibitors CFD, CFH, CFB MEN1 1819/4885KMT2A 4445/4885KDM4E 4172/4885
US-20250186391-A1 ORAL COMPLEMENT FACTOR D INHIBITORS CFD, CFH, CFB MEN1 548/4885KMT2A 4835/4885KDM4E 4491/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.