Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
| ▸ | ELANE | P08246 | 2/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ICMT | O60725 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29853133 | 1.00 | CFD (0.42) | CFDDPP4MAPTALDH1A1CD274 | |
| SCHEMBL23218950 | 0.91 | DPP4 (0.39) | CFDDPP4MAPTALDH1A1KDM4E | |
| SCHEMBL29852921 | 0.91 | DPP4 (0.39) | CFDDPP4MAPTALDH1A1KDM4E | |
| SCHEMBL29591865 | 0.91 | CFD (0.43) | CFDMAPTCD274SCN9AP2RX3 | |
| SCHEMBL23218951 | 0.91 | CFD (0.43) | CFDMAPTCD274SCN9AP2RX3 | |
| SCHEMBL23218829 | 0.87 | CFD (0.52) | CFDDPP4MAPTALDH1A1KDM4E | |
| SCHEMBL29852718 | 0.87 | CFD (0.52) | CFDDPP4MAPTALDH1A1KDM4E | |
| SCHEMBL29122309 | 0.86 | CFD (0.37) | CFDDPP4MAPTALDH1A1KDM4E | |
| SCHEMBL23218704 | 0.84 | CFD (0.39) | CFDDPP4MAPTALDH1A1KDM4E | |
| SCHEMBL29340341 | 0.83 | P2RX3 (0.42) | CFDMAPTALDH1A1KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |