Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 3/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 2/20 | 0.36 |
| ▸ | ICMT | O60725 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | GYS1 | P13807 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29591865 | 1.00 | CFD (0.43) | CFDCD274AKR1C3P2RX3SCN9A | |
| SCHEMBL23219030 | 0.91 | CFD (0.42) | CFDCD274P2RX3SCN9AICMT | |
| SCHEMBL29853133 | 0.91 | CFD (0.42) | CFDCD274P2RX3SCN9AICMT | |
| SCHEMBL29593254 | 0.90 | AKR1C3 (0.37) | CFDCD274AKR1C3P2RX3SCN9A | |
| SCHEMBL23218815 | 0.90 | AKR1C3 (0.37) | CFDCD274AKR1C3P2RX3SCN9A | |
| SCHEMBL23218852 | 0.86 | CFD (0.50) | CFDP2RX3PLAUPLGF11 | |
| SCHEMBL29591491 | 0.86 | CFD (0.50) | CFDP2RX3PLAUPLGF11 | |
| SCHEMBL29121568 | 0.85 | P2RX3 (0.37) | CFDCD274AKR1C3P2RX3SCN9A | |
| SCHEMBL23218690 | 0.83 | CFD (0.37) | CFDAKR1C3P2RX3AKR1C2PLAU | |
| SCHEMBL29592684 | 0.83 | CFD (0.37) | CFDAKR1C3P2RX3AKR1C2PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |