Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23218320 | 0.78 | NLRP3 (0.42) | MAPTLMNANLRP3DNM1SMN1; SMN2 | |
| SCHEMBL23219248 | 0.78 | ROCK1 (0.40) | KDM4EKMT2AMEN1TSHRESR1 | |
| SCHEMBL28736106 | 0.75 | CMKLR1 (0.47) | KDM4EKMT2ACMKLR1 | |
| SCHEMBL15970798 | 0.71 | MAPK8 (0.40) | KMT2AMEN1MAPTLMNANLRP3 | |
| SCHEMBL23467048 | 0.71 | NLRP3 (0.40) | KMT2AMEN1MAPTLMNANLRP3 | |
| SCHEMBL15687394 | 0.71 | SYK (0.43) | KDM4EPIK3CDABL1EGFRHCK | |
| SCHEMBL17195540 | 0.70 | NLRP3 (0.43) | KMT2AEGFRMEN1MAPTLMNA | |
| SCHEMBL13322762 | 0.70 | PDGFRA (0.44) | KMT2APIK3CDABL1EGFRHCK | |
| SCHEMBL11689307 | 0.70 | KDM4E (0.37) | KDM4EKMT2ACMKLR1PIK3CDABL1 | |
| SCHEMBL29770858 | 0.70 | SYK (0.42) | KDM4ECMKLR1PIK3CDABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |