Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 9/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | ACACA | Q13085 | 5/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21605563 | 1.00 | ACACB (0.51) | ACACBKMT2ADRD2ACACAEPHX1 | |
| SCHEMBL190838 | 0.87 | KMT2A (0.56) | ACACBKMT2ADRD2ACACAEPHX1 | |
| SCHEMBL4377073 | 0.87 | KMT2A (0.56) | ACACBKMT2ADRD2ACACAEPHX1 | |
| SCHEMBL3816616 | 0.87 | KMT2A (0.56) | ACACBKMT2ADRD2ACACAEPHX1 | |
| SCHEMBL3942686 | 0.87 | KMT2A (0.56) | ACACBKMT2ADRD2ACACAEPHX1 | |
| SCHEMBL24612511 | 0.87 | ACACB (0.50) | ACACBKMT2ADRD2ACACAEPHX1 | |
| Formaldehyde SCHEMBL28082239 | 0.84 | KMT2A (0.54) | ACACBKMT2ADRD2ACACAEPHX1 | |
| Bicarbonate SCHEMBL1580718 | 0.84 | KMT2A (0.57) | ACACBKMT2ADRD2ACACAEPHX1 | |
| SCHEMBL7817527 | 0.82 | ACACB (0.49) | ACACBKMT2ADRD2ACACAEPHX1 | |
| SCHEMBL20855666 | 0.82 | ACACB (0.49) | ACACBKMT2ADRD2ACACAEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11345666-B2 | Phenyl and pyridinyl substituted imidazoles as modulators of RORγT | JANSSEN PHARMACEUTICA NV (BE) | 2022-05-31 | — | — | US | disclosed |
| US-10975037-B2 | Phenyl substituted pyrazoles as modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2021-04-13 | — | — | US | disclosed |
| US-10975057-B2 | 6-aminopyridin-3-yl pyrazoles as modulators of RORgT | JANSSEN PHARMACEUTICA NV (BE) | 2021-04-13 | — | — | US | disclosed |
| CN-112566901-A | Phenyl-substituted pyrazoles as modulators of ROR γ t | 詹森药业有限公司 | 2021-03-26 | — | — | CN | disclosed |
| CN-112334450-A | Phenyl and pyridyl substituted imidazoles as modulators of ROR γ t | 詹森药业有限公司 | 2021-02-05 | — | — | CN | disclosed |
| CN-112292183-A | 6-aminopyridin-3-yl-pyrazoles as modulators of ROR γ t | 詹森药业有限公司 | 2021-01-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10975037-B2 | Phenyl substituted pyrazoles as modulators of RORγt | RORC, RORB, RORA | ACACB 4082/4885KMT2A 1864/4885DRD2 1538/4885 |
| US-11345666-B2 | Phenyl and pyridinyl substituted imidazoles as modulators of RORγT | RORC, RORB, RORA | ACACB 3485/4885KMT2A 1380/4885DRD2 2087/4885 |
| US-10975057-B2 | 6-aminopyridin-3-yl pyrazoles as modulators of RORgT | RORC, RORA, RORB | ACACB 3098/4885KMT2A 878/4885DRD2 2076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.