SCHEMBL23223751

SCHEMBL23223751

Fc1ccc(C2(Oc3cccc(F)c3)CNC2)cc1

nearest known ligand 0.39

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 10/20 0.39
SLC6A4 P31645 9/20 0.39
SLC6A3 Q01959 9/20 0.39
HTR1A P08908 3/20 0.39
NPY5R Q15761 2/20 0.38
GRM5 P41594 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23223779 0.91 SLC6A2 (0.39) SLC6A2SLC6A4SLC6A3HTR1A
Hydrochloric Acid SCHEMBL23203059 0.89 SLC6A2 (0.38) SLC6A2SLC6A4SLC6A3HTR1A
Trifluoroacetic Acid SCHEMBL23203193 0.88 PPARG (0.37) SLC6A2SLC6A4SLC6A3HTR1A
SCHEMBL23223655 0.79 SLC6A2 (0.36) SLC6A2SLC6A4SLC6A3HTR1ANPY5R
Hydrochloric Acid SCHEMBL23203164 0.78 SLC6A2 (0.35) SLC6A2SLC6A4SLC6A3HTR1ANPY5R
Trifluoroacetic Acid SCHEMBL23467099 0.76 SLC6A2 (0.41) SLC6A2SLC6A4SLC6A3
SCHEMBL8271672 0.76 SLC6A4 (0.40) SLC6A2SLC6A4SLC6A3HTR1A
SCHEMBL23203050 0.75 MGLL (0.40) GRM5
Hydrochloric Acid SCHEMBL4126360 0.74 SLC6A4 (0.39) SLC6A2SLC6A4SLC6A3HTR1A
SCHEMBL20757563 0.71 LIPG (0.36) SLC6A2SLC6A4SLC6A3NPY5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230097700-A1 AZETIDINE SULFONAMIDE COMPOUND DAIICHI SANKYO COMPANY, LIMITED (JP) 2023-03-30 US disclosed
EP-4082611-A1 AZETIDINE SULFONAMIDE COMPOUND Daiichi Sankyo Company, Limited (JP) 2022-11-02 EP disclosed
US-20210238136-A1 AZETIDINE DERIVATIVE, AND PRODRUG THEREOF DAIICHI SANKYO COMPANY, LIMITED (JP) 2021-08-05 US disclosed
WO-2021112251-A1 AZETIDINE SULFONAMIDE COMPOUND 第一三共株式会社 2021-06-10 WO disclosed
EP-3805203-A1 AZETIDINE DERIVATIVE, AND PRODRUG THEREOF Daiichi Sankyo Company, Limited (JP) 2021-04-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210238136-A1 AZETIDINE DERIVATIVE, AND PRODRUG THEREOF IFNG, IFNAR1, TLR9 SLC6A2 344/4885SLC6A4 1304/4885SLC6A3 279/4885
US-20230097700-A1 AZETIDINE SULFONAMIDE COMPOUND IFNG, IFNAR1, STAT1 SLC6A2 414/4885SLC6A4 545/4885SLC6A3 556/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.