Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 2/20 | 0.60 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.57 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.52 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 10/20 | 0.48 |
| ▸ | MMP3 | P08254 | 8/20 | 0.48 |
| ▸ | MMP1 | P03956 | 7/20 | 0.48 |
| ▸ | MMP7 | P09237 | 6/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24829473 | 0.88 | SSTR3 (0.57) | CALCRLSSTR3ITGB3ITGA2BPSMB5 | |
| SCHEMBL19456877 | 0.86 | SSTR3 (0.54) | CALCRLSSTR3ITGB3ITGA2BPSMB5 | |
| SCHEMBL16854865 | 0.85 | CALCRL (0.54) | CALCRLSSTR3 | |
| SCHEMBL30583376 | 0.84 | CALCRL (0.58) | CALCRLMMP3MMP1 | |
| SCHEMBL31720861 | 0.84 | ITGB3 (0.62) | ITGB3ITGA2BGRIA1 | |
| SCHEMBL23286123 | 0.84 | CALCRL (0.52) | CALCRLSSTR3ITGB3ITGA2BGRIA1 | |
| SCHEMBL13166473 | 0.82 | SPHK1 (0.50) | SSTR3MMP2MMP3MMP1 | |
| SCHEMBL27058431 | 0.81 | CALCRL (0.55) | CALCRLSSTR3PSMB5 | |
| SCHEMBL14140557 | 0.81 | LTA4H (0.52) | CALCRLSSTR3PSMB5MMP2MMP3 | |
| SCHEMBL19719375 | 0.81 | LTA4H (0.52) | CALCRLSSTR3PSMB5MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021072203-A1 | TGFBETAR1 INHIBITOR-ASGR ANTIBODY CONJUGATES AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |