Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 2/20 | 0.54 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.54 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.44 |
| ▸ | FURIN | P09958 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16984908 | 0.91 | CALCRL (0.51) | CALCRLSSTR3KDM1AMAOAHDAC8 | |
| SCHEMBL23230052 | 0.85 | CALCRL (0.60) | CALCRLSSTR3 | |
| SCHEMBL14140557 | 0.81 | LTA4H (0.52) | CALCRLSSTR3PLGLTA4H | |
| SCHEMBL19719375 | 0.81 | LTA4H (0.52) | CALCRLSSTR3PLGLTA4H | |
| SCHEMBL23425577 | 0.81 | KLKB1 (0.45) | CALCRLSSTR3HDAC4PLGCHRND | |
| SCHEMBL12412728 | 0.80 | MMP1 (0.51) | CALCRL | |
| SCHEMBL23286081 | 0.79 | SSTR3 (0.53) | CALCRLSSTR3KDM1AMAOA | |
| SCHEMBL25083560 | 0.77 | SSTR3 (0.56) | CALCRLSSTR3SMN1; SMN2FURIN | |
| SCHEMBL14129702 | 0.77 | CPA1 (0.42) | SSTR3 | |
| SCHEMBL25083563 | 0.76 | CALCRL (0.56) | CALCRLSSTR3SMN1; SMN2FURINPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9198978-B2 | Immunoconjugates with an intracellularly-cleavable linkage | IMMUNOMEDICS, INC. (US) | 2015-12-01 | — | — | US | disclosed |
| US-20150202320-A1 | Dosages of Immunoconjugates of Antibodies and SN-38 for Improved Efficacy and Decreased Toxicity | IMMUNOMEDICS, INC. | 2015-07-23 | — | — | US | disclosed |
| US-20150174269-A1 | Immunoconjugates with an Intracellularly-Cleavable Linkage | IMMUNOMEDICS, INC. | 2015-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150202320-A1 | Dosages of Immunoconjugates of Antibodies and SN-38 for Improved Efficacy and Decreased Toxicity | CD74, CD2, CD22 | CALCRL 2838/4885SSTR3 942/4885KDM1A 4555/4885 |
| US-20150174269-A1 | Immunoconjugates with an Intracellularly-Cleavable Linkage | CD47, CD44, DNPEP | CALCRL 3256/4885SSTR3 2563/4885KDM1A 4008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.