Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | ACP3 | P15309 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | TDO2 | P48775 | 2/20 | 0.40 |
| ▸ | IDO2 | Q6ZQW0 | 2/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2328728 | 1.00 | AOC3 (0.51) | AOC3ADRB2ADRB1HIF1ACYP2D6 | |
| SCHEMBL2319714 | 1.00 | AOC3 (0.51) | AOC3ADRB2ADRB1HIF1ACYP2D6 | |
| SCHEMBL25425418 | 0.81 | TSHR (0.42) | ADRB1HIF1ANFKB1BLMCYP3A4 | |
| SCHEMBL2322728 | 0.79 | ALDH1A1 (0.38) | CYP3A4TDP1TSHRLMNAKDM4E | |
| SCHEMBL2322514 | 0.79 | CES2 (0.42) | CYP2D6CYP3A4IDO1TDO2GAA | |
| SCHEMBL2319920 | 0.79 | CES2 (0.42) | CYP2D6CYP3A4IDO1TDO2GAA | |
| SCHEMBL2320175 | 0.79 | CES2 (0.42) | CYP2D6CYP3A4IDO1TDO2GAA | |
| SCHEMBL2323236 | 0.78 | ADRB1 (0.55) | AOC3ADRB2ADRB1HIF1ACYP2D6 | |
| SCHEMBL2319712 | 0.78 | ADRB1 (0.55) | AOC3ADRB2ADRB1HIF1ACYP2D6 | |
| SCHEMBL2328723 | 0.78 | ADRB1 (0.55) | AOC3ADRB2ADRB1HIF1ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120302546-A1 | NOVEL SULFAMIDES EXHIBITING NEUROPROTECTIVE ACTION AND METHODS FOR USE THEREOF | FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) | 2012-11-29 | — | — | US | claimed |
| WO-2011097337-A1 | NOVEL SULFAMIDES EXHIBITING NEUROPROTECTIVE ACTION AND METHODS FOR USE THEREOF | ADVANCED NEURAL DYNAMICS, INC. (US) | 2011-08-11 | — | — | WO | claimed |
| US-20120302546-A1 | NOVEL SULFAMIDES EXHIBITING NEUROPROTECTIVE ACTION AND METHODS FOR USE THEREOF | FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) | 2012-11-29 | — | — | US | disclosed |
| WO-2011097337-A1 | NOVEL SULFAMIDES EXHIBITING NEUROPROTECTIVE ACTION AND METHODS FOR USE THEREOF | ADVANCED NEURAL DYNAMICS, INC. (US) | 2011-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302546-A1 | NOVEL SULFAMIDES EXHIBITING NEUROPROTECTIVE ACTION AND METHODS FOR USE THEREOF | GRIK2, GRIK5, GRIN2A | AOC3 2836/4885ADRB2 3314/4885ADRB1 3363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.