Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.48 |
| ▸ | METAP2 | P50579 | 2/20 | 0.48 |
| ▸ | METAP1 | P53582 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MMP14 | P50281 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4359138 | 0.74 | TRPV1 (0.43) | KDM4EMAPTLMNAHSP90AA1METAP2 | |
| SCHEMBL22121720 | 0.74 | TRPV1 (0.35) | KDM4EMAPTLMNAHSP90AA1METAP2 | |
| SCHEMBL3764679 | 0.74 | CCR1 (0.43) | KDM4EMAPTLMNAHSP90AA1METAP2 | |
| SCHEMBL247512 | 0.74 | L3MBTL1 (0.52) | KDM4EMAPTLMNAHSP90AA1METAP2 | |
| SCHEMBL5239248 | 0.73 | KDM4E (0.44) | KDM4EMAPTLMNAHSP90AA1ALDH1A1 | |
| SCHEMBL2023814 | 0.73 | AXL (0.39) | KDM4EMAPTLMNAALDH1A1TDP1 | |
| SCHEMBL30831937 | 0.73 | PDE4A (0.52) | KDM4EMAPTLMNAHSP90AA1METAP2 | |
| SCHEMBL29416394 | 0.73 | PDE4A (0.52) | KDM4EMAPTLMNAHSP90AA1METAP2 | |
| SCHEMBL1065478 | 0.73 | PDE4A (0.52) | KDM4EMAPTLMNAHSP90AA1METAP2 | |
| SCHEMBL3151611 | 0.73 | HSP90AA1 (0.45) | KDM4EMAPTLMNAHSP90AA1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104086543-A | Method for preparing 4-chloro-1,8-naphthyridine | Hunan huateng pharmaceutical co ltd | 2014-10-08 | — | — | CN | claimed |
| CN-118369312-A | Trirylene diimide and tetrarylene terephthalimide colorants | 巴斯夫欧洲公司 | 2024-07-19 | — | — | CN | disclosed |
| CN-114249691-B | Naphthalimide enhanced mercury ion fluorescent probe, preparation method and application | 济南大学 | 2023-09-26 | — | — | CN | disclosed |
| CN-113166076-A | Heterocyclic compounds for the treatment of epilepsy | 大塚制药株式会社 | 2021-07-23 | — | — | CN | disclosed |
| EP-3133074-B1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-12-09 | — | — | EP | disclosed |
| US-20200031811-A1 | SUBSTITUTED MONO- AND POLYAZANAPHTHALENE DERIVATIVES AND THEIR USE | BASILEA PHARM INT AG (CH) | 2020-01-30 | — | — | US | disclosed |
| EP-2531500-B1 | HETARYL-[1,8]NAPHTHYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-01-24 | — | — | EP | disclosed |
| US-20180002321-A1 | SUBSTITUTED MONO- AND POLYAZANAPHTHALENE DERIVATIVES AND THEIR USE | Basilea Pharmaceutica International AG (CH) | 2018-01-04 | — | — | US | disclosed |
| EP-3256217-A1 | SUBSTITUTED MONO- AND POLYAZANAPHTHALENE DERIVATIVES AND THEIR USE | Basilea Pharmaceutica International AG (CH) | 2017-12-20 | — | — | EP | disclosed |
| CN-107226813-A | A kind of method for preparing the bromo- 1,8- naphthridine of 4- | 长沙深橙生物科技有限公司 | 2017-10-03 | — | — | CN | disclosed |
| WO-2005021546-A1 | SUBSTITUTED NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES | AVANIR PHARMACEUTICALS (US) | 2005-03-10 | — | — | WO | disclosed |
| US-20040048865-A1 | Antagonists of chemokine receptors | BRISTOL-MYERS SQUIBB COMPANY | 2004-03-11 | — | — | US | disclosed |
| EP-0060012-B1 | 4-HALO-1,8-NAPHTHYRIDINE DERIVATIVES USEFUL AS INTERMEDIATES AND PROCESSES FOR THEIR PREPARATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-08-29 | — | — | EP | disclosed |
| EP-0018735-B1 | 1,8-NAPHTHYRIDINE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMERICAN HOME PRODUCTS CORPORATION (US) | 1983-07-27 | — | — | EP | disclosed |
| US-4350817-A | 4-Cl, Br or I-3-Carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-09-21 | — | — | US | disclosed |
| EP-0060012-A1 | 4-Halo-1,8-naphthyridine derivatives useful as intermediates and processes for their preparation | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-09-15 | — | — | EP | disclosed |
| US-4347362-A | HYPOTENSIVE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-08-31 | — | — | US | disclosed |
| US-4324893-A | 4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-04-13 | — | — | US | disclosed |
| EP-0018735-A1 | 1,8-Naphthyridine derivatives, their preparation, pharmaceutical compositions containing them | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-11-12 | — | — | EP | disclosed |
| WO-1980002287-A1 | 1,8-NAPHTHYRIDINE DERIVATIVES | AMERICAN HOME PROD (US) | 1980-10-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180002321-A1 | SUBSTITUTED MONO- AND POLYAZANAPHTHALENE DERIVATIVES AND THEIR USE | CBR3, SCO2, CBR1 | KDM4E 3811/4885MAPT 4837/4885LMNA 502/4885 |
| US-20200031811-A1 | SUBSTITUTED MONO- AND POLYAZANAPHTHALENE DERIVATIVES AND THEIR USE | CBR3, SCO2, CBR1 | KDM4E 3808/4885MAPT 4837/4885LMNA 500/4885 |
| US-20040048865-A1 | Antagonists of chemokine receptors | CXCR2, CCR1, CXCR3 | KDM4E 3036/4885MAPT 2194/4885LMNA 2737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.