Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 2/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11299370 | 0.78 | KDM4E (0.42) | KDM4EMAPTPARP1LMNAHCAR2 | |
| SCHEMBL1248587 | 0.76 | MAPT (0.58) | KDM4EMAPTPARP1LMNAAURKA | |
| SCHEMBL277430 | 0.73 | KDM4E (0.42) | KDM4EMAPTPARP1LMNAHCAR2 | |
| SCHEMBL2323949 | 0.73 | KDM4E (0.48) | KDM4EMAPTLMNAAURKAMEN1 | |
| SCHEMBL334691 | 0.72 | PARP1 (0.55) | KDM4EPARP1LMNAHCAR2AURKA | |
| SCHEMBL915425 | 0.72 | F2 (0.43) | KDM4EMAPTPARP1LMNAHCAR2 | |
| SCHEMBL11195631 | 0.70 | MAPT (0.57) | KDM4EMAPTPARP1LMNAHCAR2 | |
| SCHEMBL13629318 | 0.70 | KDM4E (0.45) | KDM4EMAPTPARP1LMNAHCAR2 | |
| SCHEMBL21895406 | 0.70 | IDO1 (0.40) | KDM4EMAPTPARP1LMNAHCAR2 | |
| SCHEMBL30727447 | 0.70 | TRPV4 (0.44) | KDM4EMAPTPARP1LMNAAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804440-B1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | WYETH CORP (US) | 2007-12-19 | — | — | EP | disclosed |
| EP-0804440-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | American Cyanamid Company (US) | 1997-11-05 | — | — | EP | disclosed |