Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MT-CO2 | P00403 | 2/20 | 0.39 |
| ▸ | CD38 | P28907 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2330315 | 0.89 | HPGD (0.44) | CD38HPGDNPC1KDM4EPOLB | |
| SCHEMBL2333876 | 0.87 | TRPV1 (0.45) | HPGDNPC1MAPTTRPV1LMNA | |
| SCHEMBL2328931 | 0.80 | PIM1 (0.44) | NPC1EPHX2NR1H4DDR1MEN1 | |
| SCHEMBL2329497 | 0.79 | CYP1A2 (0.39) | NPC1POLBALDH1A1LMNAMEN1 | |
| SCHEMBL2328729 | 0.79 | CYP1A2 (0.39) | NPC1POLBALDH1A1LMNAMEN1 | |
| SCHEMBL2108295 | 0.79 | LMNA (0.44) | MAPTTP53EPHX2NR1H4ALDH1A1 | |
| SCHEMBL2333581 | 0.78 | HPGD (0.43) | CD38HPGDKDM4EPLA2G1BPOLB | |
| SCHEMBL2328736 | 0.76 | TRPV1 (0.45) | HPGDEGLN1NPC1TRPV1MEN1 | |
| SCHEMBL2110022 | 0.71 | NPC1 (0.47) | NPC1EPHX2NR1H4MEN1KMT2A | |
| SCHEMBL1754354 | 0.71 | MAPT (0.43) | SMN1; SMN2MAPTTP53EPHX2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222631-B1 | SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER (US) | 2011-08-17 | — | — | EP | claimed |