Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2330315 | 0.90 | HPGD (0.44) | NPC1HPGDLMNAKMT2ATSHR | |
| SCHEMBL2328736 | 0.89 | TRPV1 (0.45) | TRPV1NPC1HPGDDRD2DRD4 | |
| SCHEMBL2324504 | 0.87 | MT-CO2 (0.39) | TRPV1NPC1HPGDLMNAKMT2A | |
| SCHEMBL2332522 | 0.80 | KMT2A (0.42) | NPC1HPGDKMT2ATSHRMAPT | |
| SCHEMBL1754176 | 0.80 | TRPV1 (0.45) | TRPV1DRD2DRD3LMNAMAPT | |
| SCHEMBL2333581 | 0.80 | HPGD (0.43) | HPGDKMT2A | |
| SCHEMBL2330077 | 0.73 | SMN1; SMN2 (0.47) | HPGDLMNAKMT2ATSHR | |
| SCHEMBL1754354 | 0.72 | MAPT (0.43) | LMNAMAPT | |
| SCHEMBL2332116 | 0.72 | MEN1 (0.43) | NPC1HPGDLMNAKMT2ATSHR | |
| SCHEMBL1753964 | 0.72 | MEN1 (0.49) | TRPV1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222631-B1 | SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER (US) | 2011-08-17 | — | — | EP | claimed |