Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 3/20 | 0.56 |
| ▸ | GPR27 | Q9NS67 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 5/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28355248 | 0.95 | SIRT6 (0.54) | SIRT6GPR27POLBFABP4FABP5 | |
| SCHEMBL28355481 | 0.92 | SIRT6 (0.56) | SIRT6GPR27POLBFABP4FABP5 | |
| SCHEMBL28355158 | 0.90 | SIRT6 (0.70) | SIRT6GPR27FABP4FABP5ACLY | |
| SCHEMBL28359044 | 0.83 | SIRT6 (0.69) | SIRT6GPR27FABP4FABP5ACLY | |
| SCHEMBL23260610 | 0.81 | SIRT6 (0.84) | SIRT6GPR27POLBFABP4FABP5 | |
| SCHEMBL23246163 | 0.81 | SIRT6 (0.83) | SIRT6GPR27POLBFABP4FABP5 | |
| SCHEMBL23246158 | 0.81 | SIRT6 (0.83) | SIRT6GPR27POLBFABP4FABP5 | |
| SCHEMBL28883674 | 0.81 | SIRT6 (0.83) | SIRT6GPR27POLBFABP4FABP5 | |
| SCHEMBL28355358 | 0.81 | SIRT6 (0.83) | SIRT6GPR27POLBFABP4FABP5 | |
| SCHEMBL29561258 | 0.72 | SIRT6 (1.00) | SIRT6GPR27FABP4FABP5ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021073629-A1 | COMPOUND HAVING EFFECT OF AGONIZING SIRT6 ACETYLATION ACTIVITY, SIRT6 AGONIST AND USE THEREOF | 上海交通大学医学院 | 2021-04-22 | — | — | WO | disclosed |
| CN-110642757-A | Compound with activation SIRT6 acetylation activity, SIRT6 agonist and application thereof | 上海交通大学医学院 | 2020-01-03 | — | — | CN | disclosed |