Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 9/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 2/20 | 0.34 |
| ▸ | GCG | P01275 | 1/20 | 0.34 |
| ▸ | GRN | P28799 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2321907 | 0.76 | KDM4E (0.48) | KDM4EL3MBTL1NPSR1ALDH1A1POLB | |
| SCHEMBL2815178 | 0.70 | KDM4E (0.51) | KDM4EL3MBTL1NPSR1RXFP1ALDH1A1 | |
| SCHEMBL2814275 | 0.70 | KDM4E (0.51) | KDM4EL3MBTL1NPSR1RXFP1ALDH1A1 | |
| SCHEMBL14762280 | 0.69 | RXFP1 (0.56) | KDM4EL3MBTL1NPSR1RXFP1ALDH1A1 | |
| SCHEMBL3654673 | 0.69 | KDM4E (0.43) | KDM4EL3MBTL1NPSR1RXFP1ALDH1A1 | |
| SCHEMBL2815065 | 0.67 | KDM4E (0.50) | KDM4EL3MBTL1NPSR1RXFP1ALDH1A1 | |
| SCHEMBL14067142 | 0.66 | TDP1 (0.58) | KDM4EL3MBTL1NPSR1RXFP1ALDH1A1 | |
| SCHEMBL7463182 | 0.66 | GRN (0.68) | SMN1; SMN2GRNSORT1 | |
| SCHEMBL3579867 | 0.66 | RXFP1 (0.60) | KDM4EL3MBTL1NPSR1RXFP1ALDH1A1 | |
| SCHEMBL17014813 | 0.65 | KDM4E (0.70) | KDM4EL3MBTL1NPSR1RXFP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2357184-B1 | Imidazoquinoxaline compounds as immunomodulators | NOVARTIS AG (CH) | 2015-02-25 | — | — | EP | disclosed |
| EP-2357184-B1 | Imidazoquinoxaline compounds as immunomodulators | NOVARTIS AG (CH) | 2015-02-25 | — | — | EP | disclosed |
| US-20130101622-A1 | IMIDAZOQUINOXALINE COMPOUNDS AS IMMUNOMODULATORS | NOVARTIS AG (CH) | 2013-04-25 | — | — | US | disclosed |
| US-20130101622-A1 | IMIDAZOQUINOXALINE COMPOUNDS AS IMMUNOMODULATORS | NOVARTIS AG (CH) | 2013-04-25 | — | — | US | disclosed |
| US-8173657-B2 | Imidazoquinoxaline compounds as immunomodulators | NOVARTIS AG (CH) | 2012-05-08 | — | — | US | disclosed |
| US-8173657-B2 | Imidazoquinoxaline compounds as immunomodulators | NOVARTIS AG (CH) | 2012-05-08 | — | — | US | disclosed |
| US-8173657-B2 | Imidazoquinoxaline compounds as immunomodulators | NOVARTIS AG (CH) | 2012-05-08 | — | — | US | disclosed |
| EP-2010537-B1 | IMIDAZOQUINOXALINE COMPOUNDS AS IMMUNOMODULATORS | NOVARTIS AG (CH) | 2011-12-28 | — | — | EP | disclosed |
| EP-2010537-B1 | IMIDAZOQUINOXALINE COMPOUNDS AS IMMUNOMODULATORS | NOVARTIS AG (CH) | 2011-12-28 | — | — | EP | disclosed |
| EP-2357184-A1 | Imidazoquinoxaline compounds as immunomodulators | Novartis AG (CH) | 2011-08-17 | — | — | EP | disclosed |
| EP-2357184-A1 | Imidazoquinoxaline compounds as immunomodulators | Novartis AG (CH) | 2011-08-17 | — | — | EP | disclosed |
| US-20090311288-A1 | IMIDAZOQUINOXALINE COMPOUNDS AS IMMUNOMODULATORS | NOVARTIS AG (CH) | 2009-12-17 | — | — | US | disclosed |
| US-20090311288-A1 | IMIDAZOQUINOXALINE COMPOUNDS AS IMMUNOMODULATORS | NOVARTIS AG (CH) | 2009-12-17 | — | — | US | disclosed |
| US-20090311288-A1 | IMIDAZOQUINOXALINE COMPOUNDS AS IMMUNOMODULATORS | NOVARTIS AG (CH) | 2009-12-17 | — | — | US | disclosed |
| EP-2010537-A1 | IMIDAZOQUINOXALINE COMPOUNDS AS IMMUNOMODULATORS | Novartis AG (CH) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007109813-A1 | IMIDAZOQUINOXALINE COMPOUNDS AS IMMUNOMODULATORS | NOVARTIS AG (CH) | 2007-09-27 | — | — | WO | disclosed |
| WO-2007109813-A1 | IMIDAZOQUINOXALINE COMPOUNDS AS IMMUNOMODULATORS | NOVARTIS AG (CH) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130101622-A1 | IMIDAZOQUINOXALINE COMPOUNDS AS IMMUNOMODULATORS | IFNG, MYD88, IRF3 | KDM4E 1394/4885L3MBTL1 4776/4885NPSR1 3212/4885 |
| US-20090311288-A1 | IMIDAZOQUINOXALINE COMPOUNDS AS IMMUNOMODULATORS | IFNG, MYD88, IRF3 | KDM4E 800/4885L3MBTL1 4846/4885NPSR1 2240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.