Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
| ▸ | PRCP | P42785 | 5/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23247479 | 1.00 | CYP3A4 (0.57) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 | |
| SCHEMBL23247490 | 1.00 | CYP3A4 (0.57) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 | |
| SCHEMBL23247480 | 1.00 | CYP3A4 (0.57) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 | |
| SCHEMBL34463516 | 1.00 | CYP3A4 (0.57) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 | |
| SCHEMBL23247945 | 1.00 | CYP3A4 (0.57) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 | |
| SCHEMBL23247483 | 1.00 | CYP3A4 (0.57) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 | |
| SCHEMBL23247593 | 0.99 | CYP3A4 (0.56) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 | |
| Oxalic Acid SCHEMBL30011714 | 0.97 | PRCP (0.57) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 | |
| SCHEMBL23247529 | 0.93 | PRCP (0.51) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 | |
| SCHEMBL23247312 | 0.91 | CYP3A4 (0.56) | CYP3A4CYP2C9NR1I2KCNH2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260103459-A1 | SUBSTITUTED AZACYLES AS TRPM8 MODULATORS | GIVAUDAN SA (CH) | 2026-04-16 | — | — | US | claimed |
| US-12528801-B2 | Substituted azacyles as TRPM8 modulators | GIVAUDAN SA (CH) | 2026-01-20 | — | — | US | claimed |
| US-20250387310-A1 | COMPOSITIONS THAT ENHANCE THE COOLING EFFECT | FIRMENICH INCORPORATED (US) | 2025-12-25 | — | — | US | claimed |
| EP-4525821-A1 | COMPOSITIONS THAT ENHANCE THE COOLING EFFECT | Firmenich Incorporated (US) | 2025-03-26 | — | — | EP | claimed |
| CN-114555594-B | Substituted azacycles as TRMP modulators | 奇华顿股份有限公司 | 2025-03-18 | — | — | CN | claimed |
| US-20240358611-A1 | COMPOSITIONS | SYMRISE AG (DE) | 2024-10-31 | — | — | US | claimed |
| EP-4387587-A1 | COMPOSITIONS | Symrise AG (DE) | 2024-06-26 | — | — | EP | claimed |
| US-20240132487-A1 | SUBSTITUTED AZACYLES AS TRMP8 MODULATORS | GIVAUDAN SA (CH) | 2024-04-25 | — | — | US | claimed |
| CN-117813077-A | Composition and method for producing the same | 西姆莱斯股份公司 | 2024-04-02 | — | — | CN | claimed |
| WO-2024011086-A1 | COMPOSITIONS THAT ENHANCE THE COOLING EFFECT | FIRMENICH INCORPORATED (US) | 2024-01-11 | — | — | WO | claimed |
| WO-2023021012-A1 | COMPOSITIONS | SYMRISE AG (DE) | 2023-02-23 | — | — | WO | claimed |
| EP-4045491-A1 | SUBSTITUTED AZACYLES AS TRMP8 MODULATORS | Givaudan SA (CH) | 2022-08-24 | — | — | EP | claimed |
| CN-114555594-A | Substituted azaheterocycles as TRMP8 modulators | 奇华顿股份有限公司 | 2022-05-27 | — | — | CN | claimed |
| WO-2021074281-A1 | SUBSTITUTED AZACYLES AS TRMP8 MODULATORS | GIVAUDAN SA (CH) | 2021-04-22 | — | — | WO | claimed |
| WO-2026087386-A1 | ROSIN DIESTER COMPOUNDS AND USES THEREOF | FIRMENICH SA (CH) | 2026-04-30 | — | — | WO | disclosed |
| US-12528801-B2 | Substituted azacyles as TRPM8 modulators | GIVAUDAN SA (CH) | 2026-01-20 | — | — | US | disclosed |
| US-20250387310-A1 | COMPOSITIONS THAT ENHANCE THE COOLING EFFECT | FIRMENICH INCORPORATED (US) | 2025-12-25 | — | — | US | disclosed |
| EP-4045491-A1 | SUBSTITUTED AZACYLES AS TRMP8 MODULATORS | Givaudan SA (CH) | 2022-08-24 | — | — | EP | disclosed |
| CN-114555594-A | Substituted azaheterocycles as TRMP8 modulators | 奇华顿股份有限公司 | 2022-05-27 | — | — | CN | disclosed |
| WO-2021074281-A1 | SUBSTITUTED AZACYLES AS TRMP8 MODULATORS | GIVAUDAN SA (CH) | 2021-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260103459-A1 | SUBSTITUTED AZACYLES AS TRPM8 MODULATORS | TRPM8, TRPM7, TRPM5 | CYP3A4 2317/4885CYP2C9 2180/4885NR1I2 592/4885 |
| US-20240358611-A1 | COMPOSITIONS | AZI2, NISCH, CIP2A | CYP3A4 1038/4885CYP2C9 3086/4885NR1I2 2860/4885 |
| US-20240132487-A1 | SUBSTITUTED AZACYLES AS TRMP8 MODULATORS | TRPM8, TRPM7, TRPM5 | CYP3A4 1746/4885CYP2C9 1646/4885NR1I2 393/4885 |
| US-12528801-B2 | Substituted azacyles as TRPM8 modulators | TRPM8, TRPM7, TRPM4 | CYP3A4 2442/4885CYP2C9 2350/4885NR1I2 409/4885 |
| US-20250387310-A1 | COMPOSITIONS THAT ENHANCE THE COOLING EFFECT | TAS2R30, TAS2R1, TAS2R20 | CYP3A4 1119/4885CYP2C9 915/4885NR1I2 1263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.