SCHEMBL232480

SCHEMBL232480

CCSC(N)=NCCC[C@H](N)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NOS1 P29475 10/20 1.00
NOS2 P35228 9/20 1.00
NOS3 P29474 6/20 1.00
CYP2C19 P33261 3/20 0.71
THPO P40225 1/20 0.71
DDAH1 O94760 5/20 0.64
MEN1 O00255 1/20 0.63
KMT2A Q03164 1/20 0.63
CYP1A2 P05177 2/20 0.62
TSHR P16473 2/20 0.62
GLA P06280 1/20 0.62
NFKB1 P19838 1/20 0.62
APEX1 P27695 1/20 0.62
CYP3A4 P08684 1/20 0.57
BLM P54132 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9115754 0.88 NOS1 (0.78) NOS1NOS2NOS3CYP2C19THPO
SCHEMBL9141669 0.86 NOS1 (0.76) NOS1NOS2NOS3CYP2C19THPO
SCHEMBL29941582 0.85 NOS1 (0.74) NOS1NOS2NOS3CYP2C19THPO
SCHEMBL9113062 0.85 NOS1 (0.74) NOS1NOS2NOS3CYP2C19THPO
SCHEMBL9114350 0.84 NOS1 (0.73) NOS1NOS2NOS3CYP2C19THPO
S-Methyl-D-Thiocitrulline SCHEMBL9114394 0.83 NOS1 (1.00) NOS1NOS2NOS3CYP2C19THPO
Thiocitrulline SCHEMBL940520 0.83 NOS1 (1.00) NOS1NOS2NOS3CYP2C19THPO
SCHEMBL9141622 0.83 NOS2 (0.71) NOS1NOS2NOS3CYP2C19THPO
Thiocitrulline SCHEMBL4406617 0.82 NOS1 (0.97) NOS1NOS2NOS3CYP2C19THPO
Thiocitrulline SCHEMBL1320099 0.81 NOS2 (0.94) NOS1NOS2NOS3CYP2C19THPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 355 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10556005-B2 Adjuvant composition containing citrulline THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE (JP) 2020-02-11 US claimed
US-20170239348-A1 ADJUVANT COMPOSITION CONTAINING CITRULLINE THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE (JP) 2017-08-24 US claimed
US-9381242-B2 Adjuvant composition containing citrulline THE CHEMO—SERO—THERAPEUTIC RESEARCH INSTITUTE (JP) 2016-07-05 US claimed
CN-103561764-B adjuvant composition containing citrulline THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE (JP) 2015-09-16 CN claimed
US-20140065179-A1 ADJUVANT COMPOSITION CONTAINING CITRULLINE THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE (JP) 2014-03-06 US claimed
CN-103561764-A Adjuvant composition containing citrulline CHEMO SERO THERAPEUT RES INST 2014-02-05 CN claimed
EP-2684572-A1 ADJUVANT COMPOSITION CONTAINING CITRULLINE The Chemo-Sero-Therapeutic Research Institute (JP) 2014-01-15 EP claimed
US-20100158857-A1 Compositions and methods for the inhibition of endothelial nitric oxide synthase activity UNIVERSITY OF UTAH RESEARCH FOUNDATION 2010-06-24 US claimed
EP-2020998-A1 COMPOSITIONS AND METHODS FOR THE INHIBITION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE ACTIVITY University of Utah Research Foundation (US) 2009-02-11 EP claimed
WO-2007139897-A1 COMPOSITIONS AND METHODS FOR THE INHIBITION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE ACTIVITY UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2007-12-06 WO claimed
US-6656925-B2 Composition and method of treating arthritis ADVANCED MEDICAL INSTRUMENTS 2003-12-02 US claimed
JP-2002541077-A 2002-12-03 JP claimed
US-20020119952-A1 Composition and method of treating arthritis ADVANCED MEDICAL INSTRUMENTS 2002-08-29 US claimed
EP-1233786-A2 PRODUCT COMPRISING AT LEAST A NO SYNTHASE INHIBITING SUBSTANCE ASSOCIATED WITH AT LEAST A PHOSPHOLIPASE A2 INHIBITING SUBSTANCE SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2002-08-28 EP claimed
EP-1169005-A2 ASSOCIATION OF NO-SYNTHASE INHIBITOR(S) AND METABOLIC ANTIOXIDANT(S) SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2002-01-09 EP claimed
WO-2001032216-A2 PRODUCT COMPRISING AT LEAST A NO SYNTHASE INHIBITING SUBSTANCE ASSOCIATED WITH AT LEAST A PHOSPHOLIPASE A2 INHIBITING SUBSTANCE SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2001-05-10 WO claimed
WO-2000059448-A2 ASSOCIATION OF NO-SYNTHASE INHIBITOR(S) AND METABOLIC ANTIOXIDANT(S) SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2000-10-12 WO claimed
US-6043268-A Agent for treatment of viral infections Maeda, Hiroshi (JP) 2000-03-28 US claimed
EP-0939654-A1 ASSOCIATION OF NO SYNTASE INHIBITORS WITH TRAPPERS OF OXYGEN REACTIVE FORMS SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 1999-09-08 EP claimed
WO-1998009653-A1 ASSOCIATION OF NO SYNTASE INHIBITORS WITH TRAPPERS OF OXYGEN REACTIVE FORMS SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 1998-03-12 WO claimed