Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.60 |
| ▸ | GSR | P00390 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | CPB2 | Q96IY4 | 4/20 | 0.46 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.46 |
| ▸ | ARG2 | P78540 | 4/20 | 0.43 |
| ▸ | ARG1 | P05089 | 3/20 | 0.43 |
| ▸ | NOS2 | P35228 | 5/20 | 0.42 |
| ▸ | NOS1 | P29475 | 4/20 | 0.42 |
| ▸ | NOS3 | P29474 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL2325000 | 1.00 | GSR (0.67) | GSRALDH1A1MAPTPTGS1CPB2 | |
| Dl-Penicillamine SCHEMBL16011677 | 0.95 | ALDH1A1 (0.62) | GSRALDH1A1MAPTPTGS1CPB2 | |
| Penicillamine SCHEMBL16011676 | 0.95 | ALDH1A1 (0.62) | GSRALDH1A1MAPTPTGS1CPB2 | |
| Lysine SCHEMBL28207652 | 0.87 | GSR (0.50) | GSRALDH1A1MAPTPTGS1CPB2 | |
| Lysine SCHEMBL28080783 | 0.82 | GSR (0.91) | GSRCPB2RNPEPARG2ARG1 | |
| Lysine SCHEMBL18396695 | 0.82 | GSR (0.91) | GSRCPB2RNPEPARG2ARG1 | |
| Lysine SCHEMBL31541159 | 0.82 | GSR (0.91) | GSRCPB2RNPEPARG2ARG1 | |
| Lysine SCHEMBL18396696 | 0.82 | GSR (0.91) | GSRCPB2RNPEPARG2ARG1 | |
| Lysine SCHEMBL1645 | 0.82 | GSR (1.00) | GSRCPB2RNPEPARG2ARG1 | |
| Lysine SCHEMBL9439278 | 0.82 | GSR (1.00) | GSRCPB2RNPEPARG2ARG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009043114-A1 | ARSENOXIDE COMPOUND AND METHOD OF USE | NEWSOUTH INNOVATIONS PTY LIMITED (AU) | 2009-04-09 | — | — | WO | claimed |
| EP-3362071-A1 | CRYSTALLIZATION METHOD AND BIOAVAILABILITY | Grünenthal GmbH (DE) | 2018-08-22 | — | — | EP | disclosed |
| WO-2017049294-A1 | CRYSTALLIZATION METHOD AND BIOAVAILABILITY | THAR PHARMACEUTICALS, INC. (US) | 2017-03-23 | — | — | WO | disclosed |
| WO-2011097269-A9 | CRYSTALLIZATION METHOD AND BIOAVAILABILITY | THAR PHARMACEUTICALS, INC. (US) | 2012-12-27 | — | — | WO | disclosed |
| EP-2531200-A1 | CRYSTALLIZATION METHOD AND BIOAVAILABILITY | Thar Pharmaceuticals, Inc. (US) | 2012-12-12 | — | — | EP | disclosed |
| WO-2011097269-A1 | CRYSTALLIZATION METHOD AND BIOAVAILABILITY | THAR PHARMACEUTICALS, INC. (US) | 2011-08-11 | — | — | WO | disclosed |
| WO-2009043114-A1 | ARSENOXIDE COMPOUND AND METHOD OF USE | NEWSOUTH INNOVATIONS PTY LIMITED (AU) | 2009-04-09 | — | — | WO | disclosed |