Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.45 |
| ▸ | GSR | P00390 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.36 |
| ▸ | AGER | Q15109 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | ARG2 | P78540 | 4/20 | 0.34 |
| ▸ | ARG1 | P05089 | 3/20 | 0.34 |
| ▸ | NOS2 | P35228 | 3/20 | 0.34 |
| ▸ | NOS3 | P29474 | 2/20 | 0.34 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL28207684 | 0.96 | GSR (0.47) | GSRALDH1A1MAPTPTGS1CPB2 | |
| Lysine SCHEMBL28207112 | 0.87 | GSR (0.67) | GSRCPB2THRBRNPEPAGER | |
| Lysine SCHEMBL2325003 | 0.87 | GSR (0.67) | GSRALDH1A1MAPTPTGS1CPB2 | |
| Lysine SCHEMBL3868637 | 0.87 | GSR (0.67) | GSRCPB2THRBRNPEPAGER | |
| Lysine SCHEMBL2325000 | 0.87 | GSR (0.67) | GSRALDH1A1MAPTPTGS1CPB2 | |
| Dl-Penicillamine SCHEMBL16011677 | 0.82 | ALDH1A1 (0.62) | GSRALDH1A1MAPTPTGS1CPB2 | |
| Penicillamine SCHEMBL16011676 | 0.82 | ALDH1A1 (0.62) | GSRALDH1A1MAPTPTGS1CPB2 | |
| Lysine SCHEMBL28860372 | 0.81 | GSR (0.59) | GSRCPB2THRBRNPEPAGER | |
| Norleucine SCHEMBL27512040 | 0.75 | SLC1A2 (0.49) | GSRAGERNOS1CYP1A2 | |
| Lysine SCHEMBL28980840 | 0.73 | GSR (0.74) | GSRCPB2THRBRNPEPARG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107793563-B | A kind of polyethylene glycol omega-amino acid maleimide derivatives and preparation method thereof | 湖南华腾制药有限公司 | 2019-09-20 | — | — | CN | disclosed |
| CN-107793563-A | A kind of polyethylene glycol omega-amino acid maleimide derivatives and preparation method thereof | 湖南华腾制药有限公司 | 2018-03-13 | — | — | CN | disclosed |