Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 2/20 | 1.00 |
| ▸ | TLK2 | Q86UE8 | 14/20 | 0.69 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.69 |
| ▸ | NEK7 | Q8TDX7 | 1/20 | 0.69 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.69 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | CDK7 | P50613 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1395126 | 0.81 | TLK2 (1.00) | MELKTLK2MAP3K11NEK7NEK6 | |
| SCHEMBL1395124 | 0.81 | TLK2 (1.00) | MELKTLK2MAP3K11NEK7NEK6 | |
| SCHEMBL2230665 | 0.81 | TLK2 (1.00) | MELKTLK2MAP3K11NEK7NEK6 | |
| SCHEMBL29908697 | 0.81 | TLK2 (1.00) | MELKTLK2MAP3K11NEK7NEK6 | |
| SCHEMBL16234139 | 0.79 | TLK2 (0.65) | MELKTLK2MAP3K11NEK7NEK6 | |
| SCHEMBL16234142 | 0.74 | TLK2 (0.60) | MELKTLK2MAP3K11NEK7NEK6 | |
| SCHEMBL16234143 | 0.73 | TLK2 (0.64) | MELKTLK2MAP3K11NEK7NEK6 | |
| SCHEMBL16234144 | 0.72 | TLK2 (0.57) | MELKTLK2MAP3K11NEK7NEK6 | |
| SCHEMBL16234138 | 0.72 | TLK2 (0.56) | MELKTLK2MAP3K11NEK7NEK6 | |
| SCHEMBL16234137 | 0.71 | TLK2 (0.55) | MELKTLK2MAP3K11NEK7NEK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210317107-A1 | INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2021-10-14 | — | — | US | disclosed |
| US-10981896-B2 | Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317107-A1 | INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | MELK, HIPK1, HIPK3 | MELK 1/4885TLK2 29/4885MAP3K11 383/4885 |
| US-10981896-B2 | Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase | MELK, HIPK1, HIPK3 | MELK 1/4885TLK2 30/4885MAP3K11 372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.