Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 14/20 | 1.00 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 1.00 |
| ▸ | NEK7 | Q8TDX7 | 1/20 | 1.00 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 1.00 |
| ▸ | MELK | Q14680 | 2/20 | 0.69 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | CDK7 | P50613 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2230665 | 1.00 | TLK2 (1.00) | TLK2MAP3K11NEK7NEK6MELK | |
| SCHEMBL1395124 | 1.00 | TLK2 (1.00) | TLK2MAP3K11NEK7NEK6MELK | |
| SCHEMBL1395126 | 1.00 | TLK2 (1.00) | TLK2MAP3K11NEK7NEK6MELK | |
| SCHEMBL16231615 | 0.82 | TLK2 (0.70) | TLK2MAP3K11NEK7NEK6MELK | |
| SCHEMBL23252181 | 0.81 | MELK (1.00) | TLK2MAP3K11NEK7NEK6MELK | |
| SCHEMBL16234131 | 0.81 | TLK2 (0.69) | TLK2MAP3K11NEK7NEK6MELK | |
| SCHEMBL16234132 | 0.81 | MAP3K11 (0.68) | TLK2MAP3K11NEK7NEK6MELK | |
| SCHEMBL16234139 | 0.79 | TLK2 (0.65) | TLK2MAP3K11NEK7NEK6MELK | |
| SCHEMBL16234143 | 0.78 | TLK2 (0.64) | TLK2MAP3K11NEK7NEK6MELK | |
| SCHEMBL9886520 | 0.78 | MAP3K11 (0.64) | TLK2MAP3K11NEK7NEK6MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4081309-A2 | ENHANCING EXPRESSION OF LINE-1 ENCODED ORF2P FOR CANCER THERAPEUTICS | The Johns Hopkins University (US) | 2022-11-02 | — | — | EP | claimed |
| CN-119031921-A | Annular RNA with 16bp-26bp double-stranded stem-loop structure for treating psoriasis or Alzheimer's disease | 中国科学院分子细胞科学卓越创新中心 | 2024-11-26 | — | — | CN | disclosed |
| EP-4081309-A2 | ENHANCING EXPRESSION OF LINE-1 ENCODED ORF2P FOR CANCER THERAPEUTICS | The Johns Hopkins University (US) | 2022-11-02 | — | — | EP | disclosed |