Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MITF | O75030 | 1/20 | 0.62 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.62 |
| ▸ | EGFR | P00533 | 8/20 | 0.54 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 2/20 | 0.52 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10641674 | 0.81 | SMN1; SMN2 (0.69) | HPGDSMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL30761786 | 0.77 | KDM4E (0.69) | HPGDALDH1A1KMT2AEGFRKDM4E | |
| SCHEMBL30761787 | 0.77 | KDM4E (0.69) | HPGDALDH1A1KMT2AEGFRKDM4E | |
| SCHEMBL17394839 | 0.77 | KDM4E (0.69) | HPGDALDH1A1KMT2AEGFRKDM4E | |
| SCHEMBL17394841 | 0.77 | KDM4E (0.69) | HPGDALDH1A1KMT2AEGFRKDM4E | |
| Hydrochloric Acid SCHEMBL30761788 | 0.76 | KDM4E (0.68) | HPGDALDH1A1KMT2AEGFRKDM4E | |
| SCHEMBL11099989 | 0.72 | ALDH1A1 (0.47) | HPGDSMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL11099991 | 0.72 | ALDH1A1 (0.47) | HPGDSMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL17392445 | 0.72 | MAPT (0.49) | HPGDSMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL17392444 | 0.72 | MAPT (0.49) | HPGDSMN1; SMN2ALDH1A1MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3303283-B1 | FTO INHIBITORS | NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) | 2021-04-21 | — | — | EP | disclosed |