Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11099991 | 1.00 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2NPC1RAB9AEGFR | |
| SCHEMBL11224571 | 0.84 | NAAA (0.51) | ALDH1A1SMN1; SMN2EGFRHPGDALOX15 | |
| SCHEMBL11108507 | 0.81 | GLO1 (0.53) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL11108502 | 0.81 | GLO1 (0.53) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL11099219 | 0.79 | EGFR (0.71) | EGFRHPGDKMT2ACYP1A2CYP2C19 | |
| SCHEMBL11099216 | 0.79 | EGFR (0.71) | EGFRHPGDKMT2ACYP1A2CYP2C19 | |
| SCHEMBL8757271 | 0.78 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2NPC1RAB9AEGFR | |
| SCHEMBL8756886 | 0.78 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2NPC1RAB9AEGFR | |
| SCHEMBL6657315 | 0.78 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2NPC1RAB9AEGFR | |
| SCHEMBL8756892 | 0.78 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2NPC1RAB9AEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0047119-B1 | CARBOXAMIDE COMPOUNDS AS SRS-A ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCESSES FOR THE PREPARATION, AND INTERMEDIATES USEFUL THEREIN | PFIZER INC. (US) | 1984-05-09 | — | — | EP | disclosed |
| US-4343813-A | ANTIANAPHYLACTIC AGENTS | PFIZER INC. (US) | 1982-08-10 | — | — | US | disclosed |
| EP-0047119-A1 | Carboxamide compounds as SRS-A antagonists, pharmaceutical compositions containing them, processes for the preparation, and intermediates useful therein | PFIZER INC. (US) | 1982-03-10 | — | — | EP | disclosed |
| US-4296120-A | ANTIANAPHYLACTIC | PFIZER INC. (US) | 1981-10-20 | — | — | US | disclosed |