Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 2/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17362153 | 0.82 | CARM1 (0.41) | SLC6A2SLC6A4SLC6A3GBA1APP | |
| SCHEMBL21153123 | 0.78 | CARM1 (0.39) | SLC6A2SLC6A4SLC6A3GBA1HRH3 | |
| SCHEMBL17553578 | 0.78 | CHRNB2 (0.49) | TSHR | |
| SCHEMBL17825464 | 0.74 | LPL (0.39) | GBA1 | |
| SCHEMBL18883044 | 0.74 | NPC1 (0.56) | — | |
| SCHEMBL15586738 | 0.74 | PEPD (0.46) | — | |
| SCHEMBL28214153 | 0.74 | CPB2 (0.39) | APP | |
| SCHEMBL17296085 | 0.74 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3GBA1 | |
| SCHEMBL26187362 | 0.74 | GBA1 (0.39) | SLC6A2SLC6A4GBA1 | |
| SCHEMBL3914733 | 0.74 | SLC6A4 (0.50) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3186224-B1 | SUBSTITUTED AZETIDINE DERIVATIVES AS TAAR LIGANDS | HOFFMANN LA ROCHE (CH) | 2021-04-21 | — | — | EP | disclosed |