Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19030923 | 0.77 | ALDH1A1 (0.40) | MAPT | |
| SCHEMBL28518232 | 0.76 | KDM4E (0.34) | MAPTLMNAFKBP1A | |
| SCHEMBL4446515 | 0.71 | OPRM1 (0.34) | MAPTLMNA | |
| SCHEMBL17397361 | 0.70 | CHRNB2 (0.39) | MAPT | |
| SCHEMBL21949878 | 0.70 | CYP2C9 (0.38) | MAPT | |
| SCHEMBL21855120 | 0.70 | CYP2D6 (0.31) | — | |
| SCHEMBL5257795 | 0.69 | CYP4F2 (0.39) | MAPTLMNAFKBP1A | |
| SCHEMBL25076093 | 0.69 | CYP4F2 (0.39) | MAPTLMNAFKBP1A | |
| SCHEMBL6848457 | 0.69 | MAPT (0.46) | MAPT | |
| SCHEMBL8305688 | 0.69 | CYP4F2 (0.41) | MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10988478-B1 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | GENENTECH, INC. (US) | 2021-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10988478-B1 | Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators | IRAK1, IRAK4, IRAK2 | MAPT 1916/4885LMNA 3215/4885TAAR1 2044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.