Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.33 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | GRN | P28799 | 1/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 3/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.32 |
| ▸ | BCL2 | P10415 | 1/20 | 0.32 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23257132 | 0.88 | POLQ (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23249219 | 0.87 | POLQ (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23250388 | 0.86 | LMNA (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL21459657 | 0.85 | POLQ (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23250348 | 0.85 | S1PR1 (0.31) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23250511 | 0.83 | POLQ (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23248918 | 0.82 | OPRK1 (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29863760 | 0.82 | POLQ (0.32) | — | |
| SCHEMBL23256173 | 0.81 | OPRK1 (0.35) | SMN1; SMN2MCL1 | |
| SCHEMBL31629365 | 0.81 | SMN1; SMN2 (0.30) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021076902-A1 | INHIBITING HUMAN INTEGRIN α 4 β 7 | MORPHIC THERAPEUTIC, INC. (US) | 2021-04-22 | — | — | WO | disclosed |
| WO-2021076890-A1 | INHIBITING HUMAN INTEGRIN α4β7 | MORPHIC THERAPEUTIC, INC. (US) | 2021-04-22 | — | — | WO | disclosed |