Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 7/20 | 0.34 |
| ▸ | BRAF | P15056 | 4/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27018494 | 0.86 | ABL1 (0.38) | ABL1BRD4CTSAELANEPIK3C3 | |
| SCHEMBL23263206 | 0.84 | ABL1 (0.37) | ABL1BRD4FYNPIK3C3 | |
| SCHEMBL23263840 | 0.84 | BRD4 (0.33) | BRD4ELANEMTNR1AMTNR1B | |
| SCHEMBL23263859 | 0.84 | MKNK1 (0.40) | ABL1BRD4ELANE | |
| SCHEMBL23263920 | 0.83 | HPGDS (0.40) | FYNAURKBGABRA1GABRG2GABRB3 | |
| SCHEMBL23263130 | 0.82 | NPSR1 (0.32) | BRD4ELANEPIK3C3MTNR1AMTNR1B | |
| SCHEMBL23263129 | 0.82 | BACE1 (0.39) | ABL1BRAFFYNRPS6KB1CSNK1D | |
| SCHEMBL27018362 | 0.80 | ELANE (0.35) | BRD4FYNELANEGABRA1GABRG2 | |
| SCHEMBL23263181 | 0.80 | GSK3B (0.35) | BRD4ELANERPS6KB1CSNK1DGSK3A | |
| SCHEMBL23263930 | 0.79 | PTGES2 (0.39) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240018105-A1 | TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS | KINESID THERAPEUTICS, INC. (US) | 2024-01-18 | — | — | US | disclosed |
| US-20240018105-A1 | TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS | KINESID THERAPEUTICS, INC. (US) | 2024-01-18 | — | — | US | disclosed |
| WO-2021076945-A1 | TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS | Ambys Medicines, Inc. (US) | 2021-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240018105-A1 | TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS | TXNRD2, TXNRD1, SDHB | ABL1 1266/4885RAF1 3486/4885BRAF 3865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.