Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 4/20 | 0.48 |
| ▸ | GBA1 | P04062 | 12/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24023303 | 0.89 | CYP19A1 (0.36) | SMPD1GBA1 | |
| SCHEMBL24849593 | 0.86 | SMPD1 (0.40) | SMPD1GBA1 | |
| SCHEMBL30736082 | 0.86 | SMPD1 (0.54) | SMPD1GBA1HRH4HRH3EPHX2 | |
| SCHEMBL16921661 | 0.86 | SMPD1 (0.38) | SMPD1GBA1 | |
| SCHEMBL24023271 | 0.84 | SMPD1 (0.40) | SMPD1GBA1 | |
| SCHEMBL10080835 | 0.83 | SMPD1 (0.50) | SMPD1GBA1HRH4HRH3EPHX2 | |
| SCHEMBL19705718 | 0.81 | SMPD1 (0.48) | SMPD1GBA1HRH4HRH3EPHX2 | |
| SCHEMBL20375449 | 0.81 | SMPD1 (0.48) | SMPD1GBA1HRH4HRH3EPHX2 | |
| SCHEMBL20878340 | 0.79 | SMPD1 (0.46) | SMPD1GBA1HRH4HRH3 | |
| SCHEMBL24775851 | 0.77 | CYP19A1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210113701-A1 | BRUSH PRODRUGS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2021-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210113701-A1 | BRUSH PRODRUGS AND USES THEREOF | ABCB11, SI, ABCB1 | SMPD1 58/4885GBA1 325/4885HRH4 4520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.