Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 3/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MIF | P14174 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28231627 | 0.70 | ALDH1A1 (0.45) | ALDH1A1ATMLMNASMN1; SMN2POLB | |
| SCHEMBL3798218 | 0.69 | LMNA (0.44) | ALDH1A1ATMLMNATSHRHPGD | |
| SCHEMBL14968017 | 0.67 | ALDH1A1 (0.45) | ALDH1A1ATMLMNASMN1; SMN2POLB | |
| SCHEMBL4703942 | 0.67 | ALDH1A1 (0.33) | ALDH1A1ATM | |
| SCHEMBL18642368 | 0.67 | ALDH1A1 (0.39) | ALDH1A1ATMLMNASMN1; SMN2POLB | |
| SCHEMBL16365924 | 0.66 | ALDH1A1 (0.44) | ALDH1A1ATMLMNASMN1; SMN2POLB | |
| SCHEMBL9017765 | 0.65 | ALDH1A1 (0.52) | ALDH1A1ATMLMNASMN1; SMN2POLB | |
| SCHEMBL25299469 | 0.65 | ALDH1A1 (0.47) | ALDH1A1ATMTSHRHPGDNAAA | |
| SCHEMBL3043065 | 0.65 | ALDH1A1 (0.52) | ALDH1A1ATMLMNASMN1; SMN2POLB | |
| SCHEMBL3807047 | 0.65 | ALDH1A1 (0.52) | ALDH1A1ATMLMNASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356125-A1 | DERIVATIVES OF OXABISPIDINE AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | Targacept, Inc. (US) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010002971-A1 | DERIVATIVES OF OXABISPIDINE AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | TARGACEPT, INC. (US) | 2010-01-07 | — | — | WO | disclosed |