Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21277825 | 0.77 | LOXL2 (0.40) | CHRM3LMNACHRM2CHRM4CHRM5 | |
| SCHEMBL10036725 | 0.72 | PTPN1 (0.44) | CHRM3LMNACHRM2CHRM4CHRM5 | |
| SCHEMBL5906945 | 0.72 | PTPN1 (0.50) | CHRM3LMNACHRM2CHRM4CHRM5 | |
| SCHEMBL28552163 | 0.69 | LMNA (0.35) | CHRM3LMNACHRM2CHRM4CHRM5 | |
| SCHEMBL29915685 | 0.69 | CHRM3 (0.41) | CHRM3LMNACHRM2CHRM4CHRM5 | |
| SCHEMBL2600399 | 0.67 | CHRM3 (0.44) | CHRM3LMNACHRM2CHRM4CHRM5 | |
| SCHEMBL3664888 | 0.67 | CA12 (0.35) | CHRM3LMNACHRM2CHRM4CHRM5 | |
| SCHEMBL18851673 | 0.66 | CHRM3 (0.36) | CHRM3LMNACHRM2CHRM4CHRM5 | |
| SCHEMBL43992 | 0.66 | — | — | |
| SCHEMBL12905841 | 0.65 | PTPN1 (0.45) | CHRM3LMNACHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189041-B1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | CTXT PTY LTD (AU) | 2021-04-28 | — | — | EP | disclosed |