Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | PDE1A | P54750 | 3/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | HCK | P08631 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27236771 | 0.76 | PDE10A (0.40) | KDM4CPDE10APDE1APDE1BPDE1C | |
| SCHEMBL27236898 | 0.76 | PDE10A (0.40) | KDM4CPDE10APDE1APDE1BPDE1C | |
| SCHEMBL25291888 | 0.76 | MAP3K12 (0.37) | KDM4CPDE10ABRD4CREBBPPDE1A | |
| SCHEMBL23273712 | 0.74 | HTT (0.44) | NR3C1NPC1RAB9APIK3CDPIK3CA | |
| SCHEMBL1406557 | 0.74 | NR3C1 (0.43) | KDM4CPDE1APDE1BPDE1CPDE4D | |
| SCHEMBL25791523 | 0.72 | CNR2 (0.43) | KDM4CBRD4CREBBPPDE1APDE1B | |
| SCHEMBL22366382 | 0.72 | KDM4C (0.42) | KDM4CHSD11B1POLBPIK3CDSRC | |
| SCHEMBL21879889 | 0.71 | TGFBR1 (0.36) | KDM4CABL1 | |
| SCHEMBL21879893 | 0.71 | TGFBR1 (0.36) | KDM4CABL1 | |
| SCHEMBL23273717 | 0.71 | PKM (0.37) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021080015-A1 | MODULATORS OF TREK (TWIK RELATED K+ CHANNELS) CHANNEL FUNCTION | ONO PHARMACEUTICAL CO., LTD. (JP) | 2021-04-29 | — | — | WO | disclosed |