Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25482210 | 0.86 | ALDH1A1 (0.43) | SLC6A4ALDH1A1KMT2ASLC6A2KDM4E | |
| SCHEMBL6546081 | 0.86 | ADRA2A (0.42) | SLC6A4ADRA2AADRA2BADRA2CKMT2A | |
| SCHEMBL10602405 | 0.83 | ADRA2A (0.40) | SLC6A4ADRA2AADRA2BADRA2CKMT2A | |
| SCHEMBL9621039 | 0.82 | ADRA2A (0.46) | SLC6A4ADRA2AADRA2BADRA2CSLC6A2 | |
| SCHEMBL21095743 | 0.80 | F2RL1 (0.39) | SLC6A4ADRA2AADRA2BADRA2CSLC6A2 | |
| SCHEMBL6547601 | 0.76 | CYSLTR2 (0.46) | SLC6A4HTR2A | |
| SCHEMBL10389148 | 0.74 | ALDH1A1 (0.41) | SLC6A4ALDH1A1KMT2ASLC6A2KDM4E | |
| SCHEMBL4843352 | 0.74 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CSLC6A2HTR2C | |
| SCHEMBL8679324 | 0.74 | SLC6A4 (0.42) | SLC6A4KMT2ASLC6A2 | |
| SCHEMBL6546993 | 0.74 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021081272-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2021-04-29 | — | — | WO | disclosed |