Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 7/20 | 0.55 |
| ▸ | RAB9A | P51151 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.43 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19651332 | 0.75 | KDM4E (0.70) | KDM4ELMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23288021 | 0.72 | MRGPRX4 (0.43) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL23288040 | 0.71 | EGFR (0.39) | — | |
| SCHEMBL25487719 | 0.71 | MTNR1A (0.44) | SMN1; SMN2MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL7119948 | 0.71 | SMN1; SMN2 (0.83) | KDM4ELMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18160436 | 0.70 | RAB9A (0.67) | KDM4ELMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16883496 | 0.70 | KDM4E (0.62) | KDM4ELMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1126145 | 0.70 | RAB9A (0.62) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL15903693 | 0.70 | SORT1 (0.71) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL15903695 | 0.70 | SORT1 (0.67) | KDM4ELMNANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021080013-A1 | INHIBITORS OF TREK (TWIK RELATED K+ CHANNELS) CHANNEL FUNCTION | ONO PHARMACEUTICAL CO., LTD. (JP) | 2021-04-29 | — | — | WO | disclosed |