Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.35 |
| ▸ | ACACB | O00763 | 2/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27240040 | 0.83 | GRM5 (0.41) | PPARGGRM5SMN1; SMN2 | |
| SCHEMBL27240259 | 0.78 | GRM5 (0.38) | PPARGGRM5SMN1; SMN2 | |
| SCHEMBL23288040 | 0.75 | EGFR (0.39) | GRM5 | |
| SCHEMBL27240244 | 0.74 | GRM5 (0.42) | PPARGGRM5SMN1; SMN2PTGES | |
| SCHEMBL23288045 | 0.72 | GRM5 (0.35) | GRM5ACACB | |
| SCHEMBL23287980 | 0.72 | NPC1 (0.39) | PPARGGRM5SMN1; SMN2 | |
| SCHEMBL23288021 | 0.70 | MRGPRX4 (0.43) | PPARGSMN1; SMN2 | |
| SCHEMBL29827331 | 0.70 | GRM5 (0.42) | PPARGGRM5SMN1; SMN2 | |
| SCHEMBL23273849 | 0.70 | GRM5 (0.42) | PPARGGRM5SMN1; SMN2 | |
| SCHEMBL23287976 | 0.69 | KDM4E (0.57) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021080013-A1 | INHIBITORS OF TREK (TWIK RELATED K+ CHANNELS) CHANNEL FUNCTION | ONO PHARMACEUTICAL CO., LTD. (JP) | 2021-04-29 | — | — | WO | disclosed |