Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2328822 | 1.00 | GAA (0.35) | GAARAB9AKDM1AALDH1A1L3MBTL1 | |
| SCHEMBL2326585 | 0.80 | KDM1A (0.37) | GAARAB9AKDM1AL3MBTL1MEN1 | |
| SCHEMBL2326589 | 0.80 | KDM1A (0.37) | GAARAB9AKDM1AL3MBTL1MEN1 | |
| SCHEMBL3090009 | 0.78 | HRH3 (0.38) | GAARAB9AKDM1AL3MBTL1MEN1 | |
| SCHEMBL3090006 | 0.78 | HRH3 (0.38) | GAARAB9AKDM1AL3MBTL1MEN1 | |
| SCHEMBL2324181 | 0.75 | SLC6A3 (0.38) | GAARAB9AKDM1AMEN1MAPK1 | |
| SCHEMBL2324177 | 0.75 | SLC6A3 (0.38) | GAARAB9AKDM1AMEN1MAPK1 | |
| SCHEMBL2325025 | 0.73 | ALOX5 (0.41) | GAARAB9AKDM1AL3MBTL1MEN1 | |
| SCHEMBL2325028 | 0.73 | ALOX5 (0.41) | GAARAB9AKDM1AL3MBTL1MEN1 | |
| SCHEMBL2328831 | 0.73 | ALDH1A1 (0.36) | ALDH1A1L3MBTL1LMNAHTTP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356113-B1 | HETEROCYCLICALLY SUBSTITUTED ARYL COMPOUNDS AS HIF INHIBITORS | BAYER IP GMBH (DE) | 2015-01-07 | — | — | EP | disclosed |
| EP-2356113-A1 | HETEROCYCLICALLY SUBSTITUTED ARYL COMPOUNDS AS HIF INHIBITORS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010054763-A1 | HETEROCYCLICALLY SUBSTITUTED ARYL COMPOUNDS AS HIF INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-05-20 | — | — | WO | disclosed |