Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 16/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15413122 | 0.85 | FGFR4 (0.46) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL20331508 | 0.71 | FGFR4 (0.47) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL15413223 | 0.71 | FGFR1 (0.61) | FGFR4FGFR1FGFR2FGFR3SRC | |
| SCHEMBL21386642 | 0.71 | FGFR4 (0.68) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL18134014 | 0.71 | FGFR4 (0.51) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL15624899 | 0.69 | FGFR4 (0.47) | FGFR4FGFR1FGFR2FGFR3SRC | |
| SCHEMBL5332258 | 0.68 | FGFR1 (0.48) | FGFR1SRCTTKAURKACCNA2 | |
| SCHEMBL8128174 | 0.67 | FGFR1 (0.47) | FGFR1SRCTTKAURKACCNA2 | |
| SCHEMBL20094066 | 0.67 | FGFR4 (0.49) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL21386706 | 0.67 | FGFR4 (0.39) | FGFR4FGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872491-B1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORP (US) | 2021-05-05 | — | — | EP | disclosed |