Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 7/20 | 0.48 |
| ▸ | SRC | P12931 | 7/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.39 |
| ▸ | CDK2 | P24941 | 4/20 | 0.39 |
| ▸ | TTK | P33981 | 4/20 | 0.39 |
| ▸ | AURKA | O14965 | 3/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | BPTF | Q12830 | 1/20 | 0.34 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8128174 | 0.88 | FGFR1 (0.47) | FGFR1SRCCCNA2CDK2TTK | |
| SCHEMBL10276720 | 0.72 | FGFR1 (0.65) | FGFR1SRCCCNA2CDK2TTK | |
| SCHEMBL23289853 | 0.68 | FGFR4 (0.54) | FGFR1SRCCCNA2CDK2TTK | |
| SCHEMBL14161581 | 0.67 | SRC (0.53) | FGFR1SRCWEE1 | |
| SCHEMBL4102042 | 0.67 | SRC (0.79) | FGFR1SRCWEE1 | |
| SCHEMBL24851981 | 0.63 | IL4I1 (0.51) | IDH1IL4I1 | |
| SCHEMBL30162723 | 0.63 | IL4I1 (0.51) | IDH1IL4I1 | |
| SCHEMBL21549765 | 0.61 | IDH1 (0.47) | IDH1ROCK1 | |
| SCHEMBL18947269 | 0.60 | GRM5 (0.48) | — | |
| SCHEMBL30634476 | 0.59 | GRIN2D (0.45) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007137867-A1 | METHODS FOR THE IDENTIFICATION OF ZAP-70 INTERACTING MOLECULES AND FOR THE PURIFICATION OF ZAP-70 | CELLZOME AG (DE) | 2007-12-06 | — | — | WO | disclosed |