Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 8/20 | 0.47 |
| ▸ | SRC | P12931 | 7/20 | 0.47 |
| ▸ | IDH1 | O75874 | 5/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | TTK | P33981 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5332258 | 0.88 | FGFR1 (0.48) | FGFR1SRCIDH1CCNA2CDK2 | |
| SCHEMBL10276720 | 0.73 | FGFR1 (0.65) | FGFR1SRCEGFRCCNA2CDK2 | |
| SCHEMBL16332688 | 0.69 | FYN (0.54) | CCNA2CDK2TTKAURKAAURKB | |
| SCHEMBL23289853 | 0.67 | FGFR4 (0.54) | FGFR1SRCCCNA2CDK2TTK | |
| SCHEMBL16332357 | 0.67 | CYP19A1 (0.53) | CCNA2CDK2TTKAURKAAURKB | |
| SCHEMBL6640590 | 0.64 | SRC (0.76) | FGFR1SRCEGFR | |
| SCHEMBL6642822 | 0.64 | FGFR1 (1.00) | FGFR1SRCEGFR | |
| SCHEMBL24852768 | 0.60 | NAMPT (0.47) | IDH1 | |
| SCHEMBL30634476 | 0.60 | GRIN2D (0.45) | IDH1 | |
| SCHEMBL30880085 | 0.60 | TTK (0.56) | CCNA2CDK2TTKAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003745-A1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY LLC (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999009030-A1 | NAPHTHYRIDINONES FOR INHIBITING PROTEIN TYROSINE KINASE AND CELL CYCLE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-02-25 | — | — | WO | disclosed |