Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 13/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 11/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30172420 | 1.00 | HDAC1 (0.51) | HDAC1HDAC6HDAC5HDAC8ALDH1A1 | |
| SCHEMBL23780448 | 0.85 | HDAC1 (0.72) | HDAC1HDAC6HDAC5HDAC8 | |
| SCHEMBL30172354 | 0.85 | HDAC1 (0.72) | HDAC1HDAC6HDAC5HDAC8 | |
| SCHEMBL23780442 | 0.82 | HDAC1 (0.69) | HDAC1HDAC6HDAC8ALDH1A1KDM4E | |
| SCHEMBL23780462 | 0.78 | HDAC1 (0.51) | HDAC1HDAC6HDAC8ALDH1A1KDM4E | |
| SCHEMBL23291921 | 0.69 | ALDH1A1 (0.63) | HDAC1HDAC6HDAC8ALDH1A1KDM4E | |
| SCHEMBL3956196 | 0.68 | ALDH1A1 (1.00) | HDAC1HDAC6HDAC8ALDH1A1KDM4E | |
| SCHEMBL4141061 | 0.68 | ALDH1A1 (1.00) | HDAC1HDAC6HDAC8ALDH1A1KDM4E | |
| SCHEMBL14363635 | 0.68 | L3MBTL1 (0.47) | HDAC1HDAC6ALDH1A1KDM4EHPGD | |
| SCHEMBL12112396 | 0.68 | L3MBTL1 (0.47) | HDAC1HDAC6HDAC5HDAC8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814343-B1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS INC (US) | 2023-01-11 | — | — | EP | claimed |
| US-12187712-B2 | Cardiac sarcomere inhibitors | CYTOKINETICS, INC. (US) | 2025-01-07 | — | — | US | disclosed |
| EP-3814343-B1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS INC (US) | 2023-01-11 | — | — | EP | disclosed |
| EP-3814343-B1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS INC (US) | 2023-01-11 | — | — | EP | disclosed |
| US-20210276991-A1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS, INC. | 2021-09-09 | — | — | US | disclosed |
| US-20210276991-A1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS, INC. | 2021-09-09 | — | — | US | disclosed |
| EP-3814343-A1 | CARDIAC SARCOMERE INHIBITORS | Cytokinetics, Inc. (US) | 2021-05-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12187712-B2 | Cardiac sarcomere inhibitors | TNNI3, TNNT2, MYLK2 | HDAC1 203/4885HDAC6 233/4885HDAC5 710/4885 |
| US-20210276991-A1 | CARDIAC SARCOMERE INHIBITORS | TNNI3, TNNT2, MYLK2 | HDAC1 203/4885HDAC6 233/4885HDAC5 710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.