SCHEMBL23292002

SCHEMBL23292002

C[Si](C)(C)CCOCn1ccc2c(Br)cnc(Cl)c21

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 5/20 0.40
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21685421 0.85 DGAT1 (0.38) DGAT1MAPT
SCHEMBL16610937 0.85 DGAT1 (0.40) DGAT1MAPT
SCHEMBL30467424 0.85 DGAT1 (0.38) DGAT1MAPT
SCHEMBL1076270 0.81 DGAT1 (0.39) DGAT1
SCHEMBL25199720 0.80 DGAT1 (0.34) DGAT1
SCHEMBL1565433 0.80 DGAT1 (0.40) DGAT1MAPT
SCHEMBL20155011 0.80 DGAT1 (0.40) DGAT1MAPT
SCHEMBL26912774 0.80 DGAT1 (0.35) DGAT1
SCHEMBL31366407 0.80 DGAT1 (0.40) DGAT1MAPT
SCHEMBL23291977 0.79 CGAS (0.35) DGAT1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3814360-A1 HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE PTC Therapeutics, Inc. (US) 2021-05-05 EP disclosed