SCHEMBL25199720

SCHEMBL25199720

C[Si](C)(C)CCOCn1ccc2c(Cl)nnc(Cl)c21

nearest known ligand 0.39

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 2/20 0.34
DUT P33316 1/20 0.32
NPC1 O15118 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23292002 0.80 DGAT1 (0.40) DGAT1
SCHEMBL30467424 0.80 DGAT1 (0.38) DGAT1
SCHEMBL21685421 0.80 DGAT1 (0.38) DGAT1
SCHEMBL15771064 0.79 DGAT1 (0.36) DGAT1DUTNPC1
SCHEMBL30729607 0.78 DGAT1 (0.39) DGAT1DUT
SCHEMBL1291499 0.76 HDAC1 (0.38) DGAT1DUTNPC1
SCHEMBL17902171 0.76 DGAT1 (0.36) DGAT1DUT
SCHEMBL1076270 0.75 DGAT1 (0.39) DGAT1DUTNPC1
SCHEMBL25253861 0.75 FGFR1 (0.35) DGAT1DUT
SCHEMBL98891 0.75 FGFR1 (0.35) DGAT1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260015357-A1 MODULATORS OF NLRP3 INFLAMMASOME AND RELATED PRODUCTS AND METHODS NEUMORA THERAPEUTICS INC (US) 2026-01-15 US disclosed
WO-2024006559-A1 MODULATORS OF NLRP3 INFLAMMASOME AND RELATED PRODUCTS AND METHODS Neumora Therapeutics, Inc. (US) 2024-01-04 WO disclosed
WO-2024006559-A1 MODULATORS OF NLRP3 INFLAMMASOME AND RELATED PRODUCTS AND METHODS Neumora Therapeutics, Inc. (US) 2024-01-04 WO disclosed
WO-2023093728-A1 BRM SELECTIVE DEGRADATION AGENT COMPOUND AND USE THEREOF 江苏先声药业有限公司 2023-06-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260015357-A1 MODULATORS OF NLRP3 INFLAMMASOME AND RELATED PRODUCTS AND METHODS NLRP3, NOD1, CASP1 DGAT1 2808/4885DUT 4500/4885NPC1 137/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.