SCHEMBL31366407

SCHEMBL31366407

C[Si](C)(C)CCOCn1ccc2c(Br)c(Cl)ncc21

nearest known ligand 0.40

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 5/20 0.40
MAPT P10636 1/20 0.34
NPC1 O15118 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30501966 0.86 DGAT1 (0.38) DGAT1MAPTNPC1
SCHEMBL22576055 0.86 DGAT1 (0.38) DGAT1MAPTNPC1
SCHEMBL22576209 0.85 DGAT1 (0.38) DGAT1MAPTNPC1
SCHEMBL112175 0.84 DGAT1 (0.39) DGAT1MAPT
SCHEMBL23292002 0.80 DGAT1 (0.40) DGAT1MAPT
SCHEMBL21768429 0.78 DGAT1 (0.40) DGAT1MAPTNPC1
SCHEMBL15667286 0.78 DGAT1 (0.35) DGAT1MAPTNPC1
SCHEMBL29717835 0.78 DGAT1 (0.35) DGAT1MAPTNPC1
SCHEMBL18975777 0.78 DGAT1 (0.40) DGAT1MAPTNPC1
SCHEMBL20535503 0.76 DGAT1 (0.36) DGAT1MAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119431358-A Pyrrolopyridines, compositions thereof and their use in medicine 中国科学院上海药物研究所 2025-02-14 CN disclosed